BACKGROUND Endovascular therapy (EVT) with stent retrievers in addition to i.v. thrombolysis (IVT) has proven effective in acute stroke patients with middle cerebral artery (MCA, M1 segment) and distal internal carotid artery (ICA) occlusion. Limited data exist concerning acute cervical ICA occlusion, either alone or in combination with intracranial ICA occlusion (tandem occlusion). Therefore w...

PURPOSE To assess the follow-up and response to treatment in patients with RAP. METHODS A retrospective follow-up study of patients with RAP diagnosed between March 2002 and August 2005. Baseline and subsequent angiograms and optical coherence tomography results were reviewed and RAP classified according to the 3 stages described by Yannuzzi. The changes observed and the best visual acuity we...

BACKGROUND The efficacy of intravenous thrombolysis (IVT) is sufficiently proven in ischemic stroke patients of middle and older age by means of randomized controlled trials and large observational studies. However, data in young stroke patients ≤50 years are still scarce. In this study, we aimed to evaluate the effectiveness and safety of IVT in young adults aged 18-50 years. Data from a conse...

Western U.S. (WUS) rainfall and snowpack vary greatly on interannual decadal timescales. This combined with their importance to water resources makes future projections of these variables highly societally relevant. Previous studies have shown that precipitation events in the WUS are influenced by timing, positioning, duration extreme integrated vapor transport (IVT) (e.g., atmospheric rivers) ...

Internal carotid artery dissection (ICAD) is an important cause of acute ischemic stroke in younger patients. Potential acute treatments include anticoagulation, intravenous thrombolysis (IVT), and endovascular thrombectomy (ET). We report a case where the use of IVT followed by ET resulted in a good clinical outcome in a patient with tandem internal carotid and middle cerebral artery occlusion...

PURPOSE To determine whether the duration of transgene expression from an alternate adenovector serotype, Ad35, can provide advantages over an Ad5 serotype vector following a single intravitreal (IVT) administration. METHODS To assess the transgene expression profile, mice received one IVT injection of Ad5- or Ad35-based vectors expressing green fluorescent protein (GFP), luciferase or pigmen...

Intraventricular tuberculoma (IVT) is extremely rare, CT and MRI patterns have been only sparsely described.  Herein, a case of intraventricular tuberculoma in a 40 year-old woman is reported.  At admission, the patient displayed malaise and was confused and deteriorated suddenly.  Brain CT and MRI findings were very similar to intraventricular meningioma.  The patient underwent surgery and tub...

purpose: to evaluate the effect of intravitreal triamcinolone acetonide (ivt) reinjection on clinical and optical coherence tomographic (oct) features in refractory diabetic macular edema (dme). methods: in an interventional case series, all ivt-treated patients enrolled in a previous clinical trial (45 subjects), were recalled for performing a new ophthalmologic examination and oct. suitable e...

intraventricular tuberculoma (ivt) is extremely rare, ct and mri patterns have been only sparsely described.  herein, a case of intraventricular tuberculoma in a 40 year-old woman is reported.  at admission, the patient displayed malaise and was confused and deteriorated suddenly.  brain ct and mri findings were very similar to intraventricular meningioma.  the patient underwent surgery and tub...

PURPOSE To determine whether repeat administration of an adenovector (Ad) into the eye results in efficient gene delivery and to test whether transgenes can be expressed from an adenovector expression system in the presence of preexisting, neutralizing anti-Ad antibodies. METHODS To assess the efficiency of repeated gene delivery of an adenovector expression system, C57Bl/6 mice received one,...