Insulin regulated aminopeptidase (IRAP) recognises "AT(4)-receptor" ligands like angiotensin IV (Ang IV) and peptidomimetics like AL-11. The metabolic stability and high affinity of [(3)H]AL-11 for catalytically active IRAP allowed its detection in Chinese hamster ovary (CHO-K1) cell membranes in the absence of chelators (Demaegdt et al., 2009). Here, we show that, contrary to [(3)H]Ang IV, [(3...

OBJECTIVE This pilot study was aimed at evaluating the efficacy and safety of a protocol-based treatment strategy combining mycophenolate mofetil (MMF), intravenous (IV) methylprednisolone (MP) pulses and low-dose glucocorticoids (GC) in early systemic sclerosis (SSc) patients suffering from either active interstitial lung disease (ILD) or extensive skin disease. PATIENTS AND METHODS Sixteen ...

Each closed oriented 3-manifoldM is naturally associated with a set of integersD(M), the degrees of all self-maps on M . D(M) is determined for each torus bundle and torus semi-bundle M . The structure of torus semi-bundle is studied in detail. The paper is a part of a project to determine D(M) for all 3-manifolds in Thurston’s picture.

Semi-domesticated plants are good resources for agroecology, because they can survive without human intervention and be managed together with non-domesticated plants. To explore the ecological know-how underlying farmer management of semi-domesticates at landscape level, we compared how Yanacona Indigenous People in southwestern Colombian Andes manage two semi-domesticated species Phaseolus bea...

This paper studies the monic semi-classical Laguerre polynomials based on previous work by Boelen and Van Assche, Filipuk et al., Clarkson Jordaan. al. proved that diagonal recurrence coefficient α n ( t ) $$ {\alpha}_n(t) satisfies fourth Painlevé equation. In this paper, we show off-diagonal β {\beta}_n(t) fulfills first member of Chazy II system. We also prove sub-leading both continuous dis...

normal 0 false false false microsoftinternetexplorer4 background: anxiety disorders are one of the most psychiatric disorders in children and adolescents that can cause long life functional disability. the first line treatment for this disorder is cognitive behavioral therapy that has primary, secondary and tertiary preventive effect, but is expensive and long time. today there is some effort t...

Ever since the introduction of fuzzy sets by L. A. Zadeh [14], the fuzzy concept has invaded almost all branches of Mathematics. The concept of fuzzy topological space was introduced and developed by C.L. Chang [3] and since then many fuzzy topologists [1,6-13] have extended various notions in classical topology to fuzzy topological spaces. The concept of somewhat continuous functions was intro...

A subset A of a space X is called regular open if A = IntA, and regular closed if X\A is regular open, or equivalently, if A= IntA. A is called semiopen [16] (resp., preopen [17], semi-preopen [3], b-open [4]) ifA⊂ IntA (resp.,A⊂ IntA,A⊂ IntA ,A⊂ IntA∪ IntA). The concept of a preopen set was introduced in [6] where the term locally dense was used and the concept of a semi-preopen set was introd...

In conclusion, I may point out that Theorem II may be generalized by a weakening of the hypothesis (d) . (1) In the first place, continuity of [a, g] f with respect to the pair of variables a, /3 may be replaced by upper semi-continuity . This generalization requires no change in the proof . (2) This continuity (or upper semi-continuity) with respect to (a, /3) is used only to show that the set...