نتایج جستجو برای: itd mutation

تعداد نتایج: 292736  

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017
Gang-Zhi Zhu Yong-Long Yang Yan-Jiao Zhang Wei Liu Mu-Peng Li Wen-Jing Zeng Xie-Lan Zhao Xiao-Ping Chen

BACKGROUND/AIMS Acute myeloid leukemia (AML) is a heterogeneous clonal disease and patients with AML who harbor an FMS-like tyrosine kinase 3 (FLT3) mutation present several dilemmas for the clinician. This study aims to identify novel targets for explaining the dilemmas. METHODS We analyzed four microarray gene expression profiles to investigate changes in whole genome expression associated ...

2013
Adam J. Mead Shabnam Kharazi Deborah Atkinson Iain Macaulay Christian Pecquet Stephen Loughran Michael Lutteropp Petter Woll Onima Chowdhury Sidinh Luc Natalija Buza-Vidas Helen Ferry Sally-Ann Clark Nicolas Goardon Paresh Vyas Stefan N. Constantinescu Ewa Sitnicka Claus Nerlov Sten Eirik W. Jacobsen

Whether signals mediated via growth factor receptors (GFRs) might influence lineage fate in multipotent progenitors (MPPs) is unclear. We explored this issue in a mouse knockin model of gain-of-function Flt3-ITD mutation because FLT3-ITDs are paradoxically restricted to acute myeloid leukemia even though Flt3 primarily promotes lymphoid development during normal hematopoiesis. When expressed in...

Hossein Ayatollahi, Hossein Rahimi, Mohammad Hadi Sadeghian, Mohammad Mehdi Kooshyar, Mohammad Reza Keramati, Sepideh Shakeri, Seyyede Fatemeh Shams,

Background and Aims: Multiple myeloma is a malignant proliferation of plasma cells derived from a single clone. The tumor, its products and the host response lead to organ damages. Some factors that are responsible in its pathogenesis are recognized. As FMS like Tyrosine Kinase 3 receptor (FLT3) mutation has been proved as a determining factor in leukemic patients the goal of this study was to ...

Journal: :Blood 2012
Vera Grossmann Susanne Schnittger Alexander Kohlmann Christiane Eder Andreas Roller Frank Dicker Christoph Schmid Clemens-Martin Wendtner Peter Staib Hubert Serve Karl-Anton Kreuzer Wolfgang Kern Torsten Haferlach Claudia Haferlach

The karyotype is so far the most important prognostic parameter in acute myeloid leukemia (AML). Molecular mutations have been analyzed to subdivide AML with normal karyotype into prognostic subsets. The aim of this study was to develop a prognostic model for the entire AML cohort solely based on molecular markers. One thousand patients with cytogenetic data were investigated for the following ...

Objective(s):Sulfur mustard (SM) was used by the Iraqi army against the Iranian troops in the Iran-Iraq war from 1983–1988. This chemical gas affects different organs including the skin, lungs and the hematopoietic system. Any exposure to SM increases the risk of chromosomal breaking, hyperdiploidy and hypodiploidy. Studies have shown that the risk for acute myeloblastic and lymphoblastic leuke...

Journal: :The Journal of biological chemistry 2005
Peili Chen Mark Levis Patrick Brown Kyu-Tae Kim Jeffrey Allebach Donald Small

Mutations in the FLT3 gene are the most common genetic alteration found in AML patients. FLT3 internal tandem duplication (ITD) mutations result in constitutive activation of FLT3 tyrosine kinase activity. The consequences of this activation are an increase in total phosphotyrosine content, persistent downstream signaling, and ultimately transformation of hematopoietic cells to factor-independe...

Journal: :Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 2006
Eva Gagyi Emoke Horváth C Bödör B Timár A Matolcsy Z Pávai

The FMS-like tyrosine kinase-3 (FLT3), which belongs to the class III receptor tyrosine kinase family, expressed by immature hematopoietic cells, plays an important role in the proliferation, differentiation and survival of stem cells. The activating mutations of FLT3 gene have been reported to be of prognostic significance. The most common somatic alteration of the FLT3 gene is the Internal Ta...

Journal: :Blood 2009
Verena Ingeborg Gaidzik Richard Friedrich Schlenk Simone Moschny Annegret Becker Lars Bullinger Andrea Corbacioglu Jürgen Krauter Brigitte Schlegelberger Arnold Ganser Hartmut Döhner Konstanze Döhner

To evaluate the incidence and clinical impact of WT1 gene mutations in younger adult patients with cytogenetically normal acute myeloid leukemia (CN-AML), sequencing of the complete coding region was performed in diagnostic samples from 617 patients who were treated on 3 German-Austrian AML Study Group protocols. WT1 mutations were identified in 78 (12.6%) of the 617 patients; mutations cluster...

Journal: :The Journal of clinical investigation 2018
Jolieke G van Oosterwijk Daelynn R Buelow Christina D Drenberg Aksana Vasilyeva Lie Li Lei Shi Yong-Dong Wang David Finkelstein Sheila A Shurtleff Laura J Janke Stanley Pounds Jeffrey E Rubnitz Hiroto Inaba Navjotsingh Pabla Sharyn D Baker

Oncogenic addiction to the Fms-like tyrosine kinase 3 (FLT3) is a hallmark of acute myeloid leukemia (AML) that harbors the FLT3-internal tandem duplication (FLT3-ITD) mutation. While FLT3 inhibitors like sorafenib show initial therapeutic efficacy, resistance rapidly develops through mechanisms that are incompletely understood. Here, we used RNA-Seq-based analysis of patient leukemic cells and...

2016
Adhra Al-Mawali David Gillis Ian Lewis

BACKGROUND Acute myeloid leukemia (AML) is a heterogeneous clonal disorder presenting with accumulation of proliferating undifferentiated blasts. Xenograft transplantation studies have demonstrated a rare population of leukemia-initiating cells called leukemic stem cells (LSCs) capable of propagating leukemia that are enriched in the CD34+/CD38- fraction. LSCs are quiescent, resistant to chemot...

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