In this work, innovative biosourced polyimide polymers were derived from novel combinations of monomers (Isosorbide, 6-FDA and amine cardo). These obtained with satisfactory yields by polycondensation different percentages isosorbide (from 100% to 0%). The synthesized polyimides had number average molecular weight in the 17,600–22,000 g/mol range, they stable well above 451 °C (5% loss N2). gla...

Number of potential drugs are underutilized due to a lack availability teratological data. Isosorbide Dinitrate is saviour drug in angina prophylaxis while chlorzoxazone skeletal muscle relaxant and there no adequate teratogenic study performed till date. This aims assess the effect these on vital organs using chick embryo model. White Leghorn’s (Gallus gallus domesticus) fertilised chicken egg...

the hypotensive effect of garlic has been well-documented in human subjects and animals. since endothelial activity regulates vascular reactivity in physiological and pathophysiological conditions, the aim of the present study was to investigate the effect of garlic on endothelium-dependent and independent relaxation of rat aorta for elucidation of mechanism of the garlic anti-hypertensive effe...

(1997). Is banding an acceptable treatment for varices that have not bled (prophylaxis)? Hepatology, 25, 1346-50. (1997). Effects of isosorbide-5-mononitrate compared with propranolol on first bleeding and long-term survival in Prevention of first bleeding in cirrhosis: a meta-analysis of randomized trials of nonsurgical treatment.

José Maria Ramos Flores, Laurent Devoize, Amélie Descheemaeker, Jean-Louis Molat, Philippe Luccarini, et al.. The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn Running Title: nitric oxide donors induced central sensitization: Nitric oxide donors induced central sensitization. Neuroscience, Else...

Purpose: To investigate the effect of isosorbide mononitrate on diabetic cardiomyopathy (DCM), and potential mechanism action.Methods: The effects + GW4869 cardiac function myocardial fibrosis in DCM rats were determined via hemodynamics, hematoxylin-eosin (H&E) staining Masson staining. Exosomes extracted from serum, differential expressions microribonucleic acids (miRNAs) related to by re...

BACKGROUND Non-steroidal anti-inflammatory drugs are considered today a very important group of medication, with a wide variety of therapeutic use, in different areas of modern medicine. Despite their beneficial effects on the patient, these drugs show a high incidence of side effects, mainly in the gastrointestinal tract. The physiopathological mechanisms of non-steroidal anti-inflammatory dru...

Ferdinand et al have written a very important and insightful review article summarizing strong evidence recommending combined isosorbide dinitrate and hydralazine therapy to reduce mortality and morbidity for AfricanAmericans with heart failure and reduced ejection fraction. The investigators have correctly pointed out that more genetic information is necessary to assess the impact of many othe...