Within a few months of the introduction of isoniazid (isonicotinic acid hydrazide) in the treatment of pulmonary tuberculosis, reports appeared of the frequent and rapid emergence of isoniazidresistant bacteria when the drug was used alone (Medical Research Council, 1952; Ferebee and Long, 1953; Lotte and Poussier, 1953; U.S. Veterans Administration, 1953). In view of earlier experience with st...

The hepatoprotective properties of Alchornea cordifolia, a medicinal plant was studied in hepatotoxicity induced animal model with high dose paracetamol or carbon tetrachloride. Knowing that antituberculosis drugs also represent risk factor for hepatotoxicity, could A. cordifolia play key role to limit their hepatotoxicity? objective this study assess the histological changes rat livers and evo...

A simple, selective, precise, and stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been established and validated for analysis of isoniazid and rifampicin both as the bulk drugs and in formulations. The compounds were separated on aluminumbacked silica gel 60 F254 plates with n-hexane–2-propanol–acetone–ammonia–formic acid, 3:3.8:2.8:0.3:0.1 (v/v) as mobile ph...

Background There is scant evidence to support target drug exposures for optimal tuberculosis outcomes. We therefore assessed whether pharmacokinetic/pharmacodynamic (PK/PD) parameters could predict 2-month culture conversion. Methods One hundred patients with pulmonary tuberculosis (65% human immunodeficiency virus coinfected) were intensively sampled to determine rifampicin, isoniazid, and p...

A search to identify new mechanisms of isoniazid resistance in Mycobacterium bovis led to the isolation of mutants defective in mycothiol biosynthesis due to mutations in genes coding for the glycosyltransferase (mshA) or the cysteine ligase (mshC). These mutants showed low-level resistance to isoniazid but were highly resistant to ethionamide. This study further illustrates that mutations in m...

Tujuan penelitian ini yaitu untuk mengetahui pengaruh pemberian dan dosis efektif ekstrak etanol batang bajakah terhadap penurunan SGOT & SGPT tikus putih jantan galur Wistar yang diinduksi isoniazid. Penelitian merupakan jenis eksperimental, dengan obyek kadar setelah diberikan senyawa uji selama 14 hari. Dosis sediaan digunakan adalah 200, 300 400 mg/kgBB. Kontrol positif silymarin 5 mg/2...

Tuberculosis (TB) is a bacterial infection caused by Mycobacterium tuberculosis which an important public health problem in Morocco. The conventional approaches employed to fight TB are good nutrition, Bacillus Calmette-Guerin (BCG) vaccination, anti-TB therapy. World Health Organization (WHO) recommends combination treatment of four drugs for two months (isoniazid (INH), rifampicin, pyrazinami...