OBJECTIVE To investigate the association between migraine and ischaemic or haemorrhagic stroke in young women. DESIGN Hospital based case-control study. SETTING Five European centres participating in the World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. SUBJECTS 291 women aged 20-44 years with ischaemic, haemorrhagic, or unclassifie...

OBJECTIVES To determine whether fibrinogen and lipid concentrations are risk factors for ischaemic stroke. DESIGN Case-control study with a population based comparison within the overall study. SETTING Oxfordshire community stroke project and a neurology clinic. SUBJECTS 105 patients who had a transient ischaemic attack or minor ischaemic stroke and 352 randomly chosen controls matched fo...

Weaning failure can be caused by myocardial ischaemia during the switch from mechanical to spontaneous ventilation. We report ischaemic left ventricular failure and ischaemic mitral insufficiency during weaning. Angiography showed that the coronary vessels were stenosed. Transluminal angioplasty made weaning possible. We conclude that acute ischaemic mitral insufficiency may contribute to cardi...

OBJECTIVE To describe the long-term outcome of different forms of symptomatic and asymptomatic ischaemic heart disease in middle-aged men. METHODS 7735 men aged 40-59, randomly selected from 24 general practices in Britain were classified into one of seven ischaemic heart disease groups according to a questionnaire and electrocardiogram (ECG): I=diagnosed myocardial infarction; II=unrecognize...

BACKGROUND Molecular mechanisms of neuroprotection that lead to ischaemic tolerance are incompletely understood. Identification of genes involved in the process would provide insight into cell survival and therapeutic approaches for stroke. We developed a mouse model of neuroprotection in stroke and did gene expression profiling to identify potential neuroprotective genes and their associated p...

AIM Patients with a recent myocardial infarction have an increased risk of recurrent ischaemic events. In the ESTEEM trial, the oral direct thrombin inhibitor ximelagatran reduced the risk of new ischaemic events when compared with placebo in aspirin treated post myocardial infarction patients. Ximelagatran persistently reduced markers of coagulation activity, i.e. prothrombin fragment 1 + 2 (F...

BACKGROUND The clinical epidemiology of stroke has been widely investigated in Caucasian populations, but the changes over time in the proportion of ischaemic to haemorrhagic strokes is less clear, especially in the Chinese population. AIMS Our objective was to study the determinants and time trends for ischaemic and haemorrhagic stroke, in relation to age, in a large Chinese population cohor...

Acute ligation of the common colic and caudal mesenteric artery in the dog led to ischaemic colitis, whereas the acute ligation of the common colic artery and gradual occlusion of the caudal mesenteric artery by an ameroid plastic device did not lead to ischaemic disease. These findings suggest that the collateral blood vessels do not open up rapidly enough to prevent ischaemic change when the ...

We report a 75-year-old male patient who suffered posterior circulation ischaemia after influenza A/H1N1 vaccination. Vaccination provokes a variable magnitude of inflammatory and immunological response that modifies the risk for ischaemic stroke. Whereas a causal relation between vaccination and ischaemic stroke is still unsettled, an inflammatory/immunological response after vaccination may t...