The inhomogeneous stochastic simulation algorithm (ISSA) is a fundamental method for spatial stochastic simulation. However, when diffusion events occur more frequently than reaction events, simulating the diffusion events by ISSA is quite costly. To reduce this cost, we propose to use the time dependent propensity function in each step. In this way we can avoid simulating individual diffusion ...

Iminoester hydrochlorides 1 have been synthesized. These compounds were then converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new series of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared. Finally a set of isatin imine derivatives 4 was obtained from the reaction of compounds 3 with isatin. The structures of all the new synthesized compounds ...

Tuberculosis (TB) remains among the world’s great public health challenges. Worldwide resurgence of TB is due to two major problems: the acquired immunodeficiency syndrome (AIDS) epidemic, which started in the mid-1980s, and the outbreak of multidrug resistant tuberculosis (MDR-TB). Thus, there is an urgent need for anti-TB drugs with improved properties such as: Enhanced activity against MDR s...

Applications of carbon-TiO2 materials have attracted attention in nanotechnology due to their synergic effects. We report the immobilization of TiO2 on carbon prepared from residues of the plant Manihot, commercial TiO2 and glycerol. The objective was to obtain a moderate loading of the anatase phase by preserving the carbonaceous external surface and micropores of the composite. Two preparatio...

A number of N-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against ADP and arachidonic acid induced platelet aggregation in human plasma was determined. The desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. The so formed compound was then act...

A number of N-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against ADP and arachidonic acid induced platelet aggregation in human plasma was determined. The desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. The so formed compound was then act...

In response to the issue of system oscillations in direct current (DC) microgrid systems with constant power loads (CPL), this paper proposes a non-singular terminal sliding-mode control (NTSMC) strategy based on improved salp swarm algorithm (ISSA). Firstly, state-feedback exact linearization technique is employed establish linearized model converter system. Then, NTSMC composite surface desig...

A green and highly effective solvent-free protocol has been reported for the synthesis of N,N′-alkylidene bisamides via the reaction of arylaldehydes (1 eq.) with primary amides (2 eq.) in the presence of saccharin-N-sulfonic acid (SaSA) as a solid-acid catalyst. The mentioned compounds have been obtained in high yields and short reaction times.

A rapid and chemoselective method for the N-formylation of structurally diverse anilines with formic acid using nanoalumina sulfonic acid (NASA) at 70oC under solvent-free condition has been developed. The catalyst was found to be compatible with different functional groups and the formylation proceeded smoothly with anilines bearing electron withdrawing as well as electron donating substituents.