This reflection paper when finalised, will replace the Reflection paper on “non-clinical studies for generic nanoparticle iron medicinal product applications” (EMA/CHMP/SWP/100094/2011) 9 10 Comments should be provided using this template. The completed comments form should be sent to [email protected] 11

Background. It is becoming increasingly clear that no single imaging modality carries all of the properties necessary for comprehensive quantitative diagnostics with high spatial and temporal resolution, high sensitivity of detection, and tomographic capability. Therefore, in order to collect truly thorough information through imaging, one needs to employ a multimodality approach. With this in ...

Ni-NTA functionalized iron oxide magnetic nanoparticle was synthesized and used to selectively immobilize a his-tagged enzyme from cell free extract as an active and recyclable nanobiocatalyst, where purification and immobilization of the target enzyme were accomplished in one pot.

A multifunctional drug delivery vehicle consisting of a tubular shaped silica host, a compact superparamagnetic iron oxide nanoparticle layer and a hyaluronic acid surface coating was developed as a theranostic platform, for in vivo MR imaging and magnetically guided/cancer targeted drug delivery.

Ultrafine individualised mono crystalline Ca(10-x)(PO4)(6-x)(HPO4)x(OH)(2-x) deficient calcium hydroxyapatite nanocrystals displaying fluorescence under visible excitation are proposed for utilisation as biocompatible biological probes.

This work presents the molecular dynamics approach toward mechanical deformation and phase transformation mechanisms of monocrystalline Si(100) subjected to nanoindentation. We demonstrate phase distributions during loading and unloading stages of both spherical and Berkovich nanoindentations. By searching the presence of the fifth neighboring atom within a nonbonding length, Si-III and Si-XII ...

The micro layers micaceous iron oxide and nano-TiO 2 were incorporated into the epoxy resin by mechanical mixing and sonication process. Optical micrographs showed that the number and diameter size of nanoparticle agglomerates were decreased by sonication. The structure and composition of the nanocomposite was determined using transmission electron microscopy which showed the presence of disper...

Metallic nanoparticles have huge applications in all the fields including agriculture and its allied sciences. This study aims at evaluating possible implications of iron oxide nanoparticles on the growth and development of rice (Oryza sativa L.). Rice is feeding hunger of half of the World’s population and yet found to be highly sensitive towards iron deficiency especially at seedling stage. T...

Iron hydroxide is found in a wide range of contexts ranging from biominerals to steel corrosion, and it can transform to anhydrous oxide via releasing O2 gas and H2O. However, it is not well understood how gases transport through a crystal lattice. Here, we present in situ observation of the nucleation and migration of gas bubbles in iron (hydr)oxide using transmission electron microscopy. We c...

Low loss core-shell iron-silica nanocomposites with improved magneto-dielectric properties at radio frequencies (1 MHz-1 GHz) were successfully fabricated. A new simple method was developed to synthesize metallic iron (Fe) nanoparticles with uniform size distribution in an aqueous environment at room temperature. Citric acid and oleic acid served as surface-capping agents to control the particl...