Iron promotes DNA damage by catalyzing hydroxyl radical formation. We examined the effect of chromatin structure on DNA susceptibility to oxidant damage. Oxygen radicals generated by H2O2, ascorbate and iron-ADP (1:2 ratio of Fe2+:ADP) extensively and randomly fragmented protein-free DNA, with double-strand breaks demonstrable even at 1 microM iron. In contrast, polynucleosomes from chicken ery...

Abstract Because of the rock carrying property drilling fluid, it is usually necessary to add bentonite and polymer into fluid improve viscosity fluid. However, will seriously affect rheological property, sand speed, degassing effect, etc. Therefore, develop a new environment-friendly low cutting agent for In this paper, konjac gum was modified by metal complexation. Some were studied. The effe...

Food iron is absorbed by the intestinal mucosa from two separate pools of heme and nonheme iron. Heme iron, derived from hemoglobin and myoglobin, is well absorbed and relatively little affected by other foods eaten in the same meal. On the other hand, the absorption of nonheme iron, the major dietary pool, is greatly influenced by meal composition. Ascorbic acid is a powerful enhancer of nonhe...

Mycobacterium tuberculosis requires iron for normal growth but faces a limitation of the metal ion due to its low solubility at biological pH and the withholding of iron by the mammalian host. The pathogen expresses the Fe(3+)-specific siderophores mycobactin and carboxymycobactin to chelate the metal ion from insoluble iron and the host proteins transferrin, lactoferrin, and ferritin. Sideroph...

The reduction of Triphos [PhP(CH(2)CH(2)PPh(2))(2)] iron halide complexes has been explored, yielding formally zerovalent (κ(3)-Triphos)Fe(κ(2)-Triphos) and (κ(3)-Triphos)Fe(κ(2)-Bpy). Electrochemical analysis, coupled with the metrical parameters of (κ(3)-Triphos)Fe(κ(2)-Bpy), reveal an electronic structure consistent with a π-radical monoanion bipyridine chelate that is antiferromagnetically ...

D ESFERRIOXAMINE (DF) is currently the most eflective chelator available for the treatment of iron overload in man.’2 Intramuscular injections reduce the rate of iron accumulation and have been shown to arrest the progress of hepatic fibrosis in children with transfusion-dependent thalassemia.3 However, used in this fashion, the drug removes a limited amount of iron, and there has been extensiv...