نتایج جستجو برای: irisin
تعداد نتایج: 926 فیلتر نتایج به سال:
The skeletal muscle-secreted myokine irisin, which is produced in response to physical 13 exercise, has several protective functions both in the central and peripheral nervous systems, 14 including regulation of brain-derived neurotrophic factor, modification of telomere length, 15 inhibition of the endoplasmic reticulum stress response, and anti-inflammatory and anti-apoptotic 16 effects that ...
Exposure to high-altitude hypoxia causes physiological and metabolic adaptive changes by disturbing homeostasis. Hypoxia-related changes in skeletal muscle affect the closely interconnected energy and regeneration processes. The balance between protein synthesis and degradation in the skeletal muscle is regulated by several molecules such as myostatin, cytokines, vitamin D, and irisin. This stu...
BACKGROUND Irisin is a new myokine secreted from the skeletal muscle and appears to affect the metabolism of adipose tissue. OBJECTIVES The mechanisms of cellular and molecular identification by which exercise training exerts its benefits remain unclear and are under investigation. METHODS We examined the effect of 8-week resistance exercise on plasma irisin levels and expression profiles o...
BACKGROUND The recent discovery of a new myokine (irisin) potentially involved in health-related training effects has gained great attention, but evidence for a training-induced increase in irisin remains preliminary. Therefore, the present study aimed to determine whether irisin concentration is increased after regular exercise training in humans. METHODS In a randomized controlled design, t...
AIM Insufficient oxygen supply to organs and tissues due to reduced arterial or venous blood flow results in ischaemia, during which, although ATP production stops, AMP and adenosine continue to be produced from ATP. The fate of irisin, which causes the production of heat instead of ATP during ischaemia, is unknown. Iloprost and sildenafil are two pharmaceutical agents that mediate the resumpti...
Background: Irisin is a myokine that secrets from muscle during and after the exercise and induces non-shivering thermogenesis after stimulation of uncoupling protein-1 (UCP1) gene expression and elevation of number and size of mitochondria. Therefore, irisin activity is effective in reduction of fat percent that lead to treatment of obesity. The aim of this review study was to investigate the ...
Irisin, a newly discovered myokine, is considered as a promising candidate for the treatment of metabolic disturbances and cardiovascular diseases. In the present study, we used two animal models, apolipoprotein E-deficient mice fed on a high-cholesterol diet and a mouse carotid partial ligation model to test the anti-atherosclerotic effect of irisin. Irisin treatment (0.5 μg/g body weight/day)...
OBJECTIVE A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet. DESIGN Ninety-three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8-week-long energy-restricted programme (-30% of...
Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA an...
It has been recently demonstrated that exercise activity increases the expression of the myokine Irisin in skeletal muscle, which is able to drive the transition of white to brown adipocytes, likely following a phenomenon of transdifferentiation. This new evidence supports the idea that muscle can be considered an endocrine organ, given its ability to target adipose tissue by promoting energy e...
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