There is a growing number of patients returning to dialysis after a failed kidney transplant, and there is increasing evidence of higher mortality among this population. Whether removal of the failed renal allograft affects survival while receiving long-term dialysis is not well understood. We identified all adults who received a kidney transplant and returned to long-term dialysis after renal ...

De novo cancers occurred after transplantation in 8,008 organ allograft recipients, who developed 8,531 different types of malignancy. Three hundred twenty-four liver recipients developed 329 cancers. There were striking differences in the patterns of neoplasms observed when these were compared with 7,200 tumors that occurred in renal allograft recipients. Lymphomas were much more common in liv...

Protocol renal allograft biopsies allow the early detection of histological damage in the renal allograft even before renal function deterioration or proteinuria appears. Two different lesions have attracted the main interest in protocol biopsy studies: subclinical rejection, namely, the presence of tubulo-interstitial inflammation and chronic allograft nephropathy, nowadays termed interstitial...

BACKGROUND Late kidney allograft failure remains a major problem in kidney transplantation. While there is no doubt that acute nephrotoxicity from calcineurin inhibitors (CNIs) exists, chronic CNI nephrotoxicity has been the subject of much debate in the transplant community. METHODS We identified original articles related to the use of CNIs in renal and extra-renal solid-organ transplantatio...

SENSITI ZA TION of potential transplant recipients by formation of Iymphocytotoxic antibodies can be a result of prior blood transfusions, pregnancy. or failed allograft transplantation. While the presence of preformed anti-HlA-A and -B Iymphocytotoxic antibodies does not appear to influence the survival of liver allografts; this has been a contraindication in renal transplantation because of t...

BACKGROUND The relative impact on renal allograft outcome of specific histological diagnoses versus nonspecific chronic histological damage remains unclear. METHODS All 1,197 renal allograft recipients who were transplanted at a single center between 1991 and 2001 were included. All posttransplant renal allograft indication biopsies performed in this cohort during follow-up (mean, 14.5±2.80 y...

An increasing number of patients with kidney transplants are found to develop abdominal aortic aneurysm (AAA) in the post-transplant period. Aortic surgery in these patients places the pelvic allograft at risk for ischaemic damage. We report successful repair of two AAA in renal transplant recipients using cold graft perfusion and local hypothermia to protect the renal allograft during aortic c...

PURPOSE To review the use of repetitive stenting in the management of patients with ureteral obstruction after renal transplantation, with an emphasis on technique and functional graft outcome. MATERIALS AND METHODS Five adult renal allograft recipients with ureteral obstruction were managed with repetitive ureteral stenting. Their hospital records, office notes, and operative reports were re...

A late dysfunction of a renal allograft refers to a progressive decline in renal function manifested)3 months after transplantation. A late dysfunction may have several causes, such as chronic rejection, chronic allograft nephropathy, chronic calcineurin inhibitor toxicity, de novo or recurrent renal disease and acute rejection. An allograft biopsy is necessary to establish a definitive diagnos...