Pyke DA, Leslie RDG. Chlorpropamide-alcohol flushing: a definition of its relation to non-insulin-dependent diabetes. Br Med J 1978;ii: 1521-2. 2 Barnett AH, Pyke DA. Chlorpropamide-alcohol flushing and large-vessel disease in non-insulin-dependent diabetes. Br MedJ7 1980;281:261-2. 3 Jerntorp P, Almer L-O. Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy...

The patient in our case presented very late for treatment with a large rapidly growing mass. We conclude that symptoms such as unusual irritation, sanguineous conjunctival discharge and focal eyelid swelling among individuals wearing ocular prostheses need prompt investigation. We also recommend regular examination and regular follow ups of the sockets of patients wearing ocular prostheses for ...

In the last 2 decades, anticholinergic agents have been generally regarded as the first-choice bronchodilator therapy in the routine management of stable chronic obstructive pulmonary disease (COPD) and, to a lesser extent, asthma. Anticholinergics are particularly important bronchodilators in COPD, because the vagal tone appears to be the only reversible component of airflow limitation in COPD...

We have measured total work of breathing before and after the inhalation of water, salbutamol, and ipratropium bromide, given as nebulised solutions, in 39 studies on 25 infants with acute, severe bronchiolitis. Twenty minutes after nebulised water, mean work of breathing per minute was increased by 4% and work per litre by 10% with 2 infants having significant improvement and 2 others showing ...

Nine patients with reversible obstructive airways disease were studied to compare the bronchodilator response to a combination of fenoterol and ipratropium aerosols with two dose levels of fenoterol alone. Using a double-blind, cross-over, single dose regime, 200 micrograms fenoterol hydrobromide and 80 micrograms ipratropium bromide was compared to 400 micrograms fenoterol + placebo, and to 20...

1. Bronchodilatation was produced in eight normal subjects by inhalation, on separate occasions, of the atropine-like drug ipratropium bromide (0.16 mg by pressurized inhaler; 1 mg nebulized) and the beta 2-sympathomimetic salbutamol (0.8 mg by pressurized inhaler; 5 mg nebulized). 2. Mean specific airways conductance (sGaw) increased from a mean value of 0.185 +/- SE 0.002 to 0.292 +/- 0.023 s...