Nocturia is a major problem in geriatric patients. Clock genes regulate circadian bladder function and Piezo type mechanosensitive ion channel component 1 (Piezo1) that senses fullness. We utilized WT mutant (ClockΔ19/Δ19: nocturia phenotype) mice to determine if the effects of GsMTx4, Piezo1 inhibitor, dependent on expression bladder. compared voiding behavior after administration vehicle, low...

In this paper an IP based network consisting of two separate networks - a virtual one, running MPLS and experimental network, connected to the have been studied. VoIP traffic is exchanged between networks. Both are Internet exchange with it. The created by using GNS3. purpose show comparison in performance addition, mathematical distributions approximations made be used further evaluate methodo...

In the current study, behavior of crank-slider mechanism with single and multiple clearance joints are analyzed. Using Lankarani-Nikravesh theory for estimating discontinuous contact forces in clearance joints, relevant systems have been mathematically modeled. Through numerical simulations, perturbations in response of mechanisms with clearance joints have been analyzed. Effects of increasing ...

Tubular KT-joints are quite common in offshore structural design and despite the crucial role of stress concentration factors (SCFs) in evaluating the fatigue performance of tubular joints. However, the SCF distribution in internally ring-stiffened KT-joints have not been investigated and no design equation is currently available to determine the SCFs for this type of joint. In the present pape...

Recent reports, from The Netherlands and the UK, suggest that statins have a modifying role in osteoarthritis (OA) using different outcome definitions, specifically radiographic OA in the Rotterdam cohort and general practitioner diagnosis from a national database in the UK study. On the other hand, a large longitudinal study from the USA found that statin use was not associated with improvemen...

The objective of this study was to determine the chemical compounds of Iranian propolis (IP) extracts and to show flavonoids and phenol effects on methane production, fermentation characteristics and rumen microbial population (in vitro). In this study two diets with different concentrate: forage ratios as (HC: high concentrate) and (MC: middle concentrate), respectively as non-supplemented or ...