The Norfolk Arthritis Register (NOAR) has been re c ruiting and fo l l ow i n g patients with early inflammatory poly-arthritis (IP) since 1989. Approximately thre e-q u a rt e rs of the patients fo l-lowed satisfy classification criteria for rheumatoid arthritis (RA) by 5 years from symptom onset. This paper sum-m a rises the publ i c ations wh i ch have been based on the NOAR cohort with resp...

Dendritic cells (DCs) patrol the interstitial space of peripheral tissues. The mechanisms that regulate their migration in such constrained environment remain unknown. We here investigated the role of calcium in immature DCs migrating in confinement. We found that they displayed calcium oscillations that were independent of extracellular calcium and more frequently observed in DCs undergoing st...

The IETF Mobile IP is the dominant standard for IP mobility support and defines two multicast options for providing multicast to mobile hosts (MHs): remote subscription (RS) and bi-directional tunneling (BT). Since the two options have complementary advantages, improved multicast support can be achieved by combining the two options. In this paper, in order to synthesize the strong points of the...

AIMS Little is known about the impact of inappropriate prescribing (IP) in community-dwelling adults, aged 80 years and older. The prevalence at baseline (November 2008September 2009) and impact of IP (misuse and underuse) after 18 months on mortality and hospitalization in a cohort of community-dwelling adults, aged 80 years and older (n = 503) was studied. METHODS Screening Tool of Older Pe...

OBJECTIVE Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diabetes, but the roles of specific ER Ca(2+) release channels in the ER stress-associated apoptosis pathway remain unknown. Here, we examined the effects of stimulating or inhibiting the ER-resident inositol trisphosphate receptors (IP(3)Rs) and the ryanodine receptors (RyRs) on the induction of beta-cell ER...

BACKGROUND Little information is available regarding eosinophil activation and cytokine profiles in relation to age in virus-induced bronchial asthma. We therefore explored the association between age, respiratory viruses, serum eosinophil cationic protein (ECP), and cytokines/chemokines in acute exacerbations of childhood asthma. METHODS We investigated viruses in nasal secretions from 88 pa...

A prominent labelled polypeptide having the same mobility as type-I inositol trisphosphate receptor (IP(3)R) was immunoprecipitated from WB-cell lysates by antibodies to calnexin, an ER integral membrane chaperone. The identity of this polypeptide was confirmed by re-immunoprecipitation of the radioactive polypeptides released from calnexin-antibody immunoprecipitates with type-I IP(3)R antibod...

BACKGROUND & OBJECTIVES Ocimum sanctum (OS) is known to possess various therapeutic properties. We have earlier isolated and characterized three OS compounds; Ocimarin, Ocimumoside A and Ocimumoside B. However, their role in modulating stress-induced central changes is unexplored. Thus, the present study was aimed to investigate the effect of these OS compounds on restraint stress (RS)-induced ...