Charged particle therapy is generally regarded as cutting-edge technology in oncology. Many proton therapy centres are active in the USA, Europe, and Asia, but only a few centres use heavy ions, even though these ions are much more effective than x-rays owing to the special radiobiological properties of densely ionising radiation. The National Institute of Radiological Sciences (NIRS) Chiba, Ja...

The Italian hadron-therapy centre CNAO (Centro Nazionale di Adroterapia Oncologica) [1] is designed for the treatment of tumours with proton and light ion beams and to clinical and radiobiological research. The design consists of two ECR ion sources, a 7 MeV/u injector linac identical to the linac of the Heidelberg ion therapy centre HIT [2][3] and a 400 MeV/u synchrotron. GSI delivers technica...

Hadron therapy (HT) with protons and carbon ions is an advanced radiotherapy technique. As the first report addressing this topic, the present study aimed to estimate the number of patients eligible for HT in Fars province and the whole of Iran. The data were collected through direct inspection of medical records of the patients treated at the Radiotherapy Department, Namazi Hospital, Shiraz, I...

PURPOSE To describe the approval process for enrolling patients on NCI-funded cooperative group clinical trials with proton therapy and the impact of data obtained from the process. METHODS Institutions interested in participating in clinical trials with proton therapy must first complete five RPC-coordinated approval steps for each proton delivery Method: a) completion of the proton facility...

Particle therapy (PT) usually uses protons and carbon ions. In addition, the use of low-Z ions (such as He, O, Ne) with higher relative biological effects than is also being investigated. Although in PT majority dose delivered to tumor volume by primary particle, a negligible additional left due contribution secondary particles produced interaction between therapeutic beam patient's tissues. pa...

High linear energy transfer (LET) radiation or heavy ion such as carbon ion radiation is used as a method for advanced radiotherapy in the treatment of cancer. It has many advantages over the conventional photon based radiotherapy using Co-60 gamma or high energy X-rays from a Linear Accelerator. However, charged particle therapy is very costly. One way to reduce the cost as well as irradiation...

BACKGROUND Ion beam has been used in cancer treatment, and has a unique preferable feature to deposit its main energy inside a human body so that cancer cell could be killed by the ion beam. However, conventional ion accelerator tends to be huge in its size and its cost. In this paper a future intense-laser ion accelerator is proposed to make the ion accelerator compact. SUBJECTS AND METHODS ...

Alpha-particle emitter labeled monoclonal antibodies are being actively developed for treatment of metastatic cancer due to the high linear energy transfer (LET) and the resulting greater biological efficacy of alpha-emitters. Our knowledge of high LET particle radiobiology derives primarily from accelerated heavy ion beam studies. In heavy ion beam therapy of loco-regional tumors, the modulati...

For real-time monitoring of the longitudinal position of the Bragg-peak during an ion therapy treatment, a novel non-invasive technique has been recently proposed that exploits the detection of prompt gamma-rays issued from nuclear fragmentation. Two series of experiments have been performed at the GANIL and GSI facilities with 95 and 305 MeV/u (12)C(6+) ion beams stopped in PMMA and water phan...