There is no simple method to measure glomerular filtration rate (GFR) in swine, an 15 established model to study renal disease. We developed a protocol to measure GFR in conscious 16 swine with the plasma clearance of iohexol. We used two groups: testing and validation, of 8 17 animals each. Ten milliliters of iohexol (6.47 g) were injected by the marginal auricular vein and 18 blood samples (3...

Arterial stiffness is a risk factor for cardiovascular and chronic kidney disease. However, the role of arterial stiffness as a predictor of the age-related glomerular filtration rate (GFR) decline in the general population remains unresolved because of difficulty in measuring GFR with sufficient precision in epidemiological studies. The ambulatory arterial stiffness index (AASI) is a proposed ...

A prospective study of 110 patients having iohexol lumbar myelograms indicates that patient positioning does not significantly influence the frequency of adverse postprocedural reactions. Thus, after the procedure, patients may be allowed to choose either ambulation or bed rest with their heads raised.

OBJECTIVES The aim of the present study was to evaluate the influence of radiographic contrast media (CM) on alteplase-induced coronary thrombolysis. BACKGROUND Contrast media inhibit fibrinolysis in vitro and interact with endothelial cells, platelets and the coagulation system. The in vivo effects of CM on thrombolysis are not known. METHODS Occlusive coronary artery thrombosis was induce...

The authors retrospectively analyzed the pattern and characteristics of non-laboratory-based adverse drug reactions (ADRs) induced by intravenous radiocontrast agents in a large-scale hospital in China during 2014-2015. There were 314 ADR cases among 118,208 patients receiving enhanced CT or MRI examinations. The frequency of moderate/severe ADRs defined by Chinese Society of Radiology (ie, sev...

BACKGROUND The timely diagnosis of acute kidney injury (AKI) in liver cirrhosis is challenging. AIM To evaluate whether quantification of glomerular filtration rate (GFR), proteinuria and kidney injury biomarkers can accurately predict the development of AKI. METHODS A prospective cohort analysis of patients with cirrhosis was performed. Measures of baseline kidney function included serum c...

BACKGROUND More than two-thirds of the world's HIV-positive individuals live in sub-Saharan Africa, where genetic susceptibility to kidney disease is high and resources for kidney disease screening and antiretroviral therapy (ART) toxicity monitoring are limited. Equations to estimate glomerular filtration rate (GFR) from serum creatinine were derived in Western populations and may be less accu...

The purpose of this study was to evaluate dendrimer-entrapped gold nanoparticles [Au DENPs] as a molecular imaging [MI] probe for computed tomography [CT]. Au DENPs were prepared by complexing AuCl4- ions with amine-terminated generation 5 poly(amidoamine) [G5.NH2] dendrimers. Resulting particles were sized using transmission electron microscopy. Serial dilutions (0.001 to 0.1 M) of either Au D...