Most drugs cannot be given orally because of significant degradation in the GIT or first pass metabolism in the liver. Nasal route for the delivery of some drugs offers an alternative in the pharmaceutical industry. The present review deals with the utility of the nasal route for the delivery of drugs to the brain as a microemulsion system in the treatment of a number of ailments like migraine,...

We have prepared a viscous bicontinuous microemulsion consisting of water / [20 wt% POE-GIS + 30 wt% PEPTME + 47.5 wt% POE/POP-PDMS + 2.5 wt% OA)] / DMPS system. A pseudoternary phase diagram was constructed for the mixture, and the bicontinuous microemulsion phase was characterized by means of rheometry and freeze-fracture transmission electron microscopy (FF-TEM).

The removal of model pollutants bromocresol green (BG) and phenol from water is demonstrated via two liquid-liquid extraction methods. Both methods exploit selective interactions established by the pollutant molecule with a surfactant, oil, or alcohol, and are variants of the more general Winsor systems where the phases are in contact along an extremely large interfacial area. In the first meth...

Nasal application of benzodiazepines might be an alternative to intravenous administration in acute clinical situations such as seizures emergencies. However, irritation and pain as well as symptoms like teary eyes, dizziness, discomfort, nasal drainage and bad taste usually accompany subject received midazolam and diazepam via the nasal route. The purpose of this study was to evaluate the use ...

Polymeric nanogel vectors were developed for cellular gene and antisense delivery. Inverse microemulsion polymerization was utilized to synthesize biocompatible nanogels with controlled size, morphology, and composition. The chemical composition, size, polydispersity, stability, and swelling behavior of the nanogels were investigated by NMR, light scattering, transmission electron microscopy, a...

In this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. The effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

In this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. The effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

Numerous types of hydrophilic polymer nanoparticles (NPs) have recently become research hotspots because their ability to dissolve in water and can be adapted with respect physical, chemical, biological properties meet the requirements different applications. Synthetic polymeric NPs had successfully gained much attention unique physicochemical properties, such as low toxicity, biodegradability,...

Mass transfer phenomenon that occurs in the pervaporation process when applied to the microemulsion breakdown, was confirmed by the results of inverse gas chromatography. The stationary phase for this study was polydimethylsiloxane (PDMS), a hydrophobic polymer employed as a membrane in the pervaporation technique. The retention times of the different molecule probes (toluene, cyclohexane, and ...

polydimethylsiloxane (pdms) has been synthesized by ring-opening polymerization of octamethylcyclotetrasiloxane (d4) in microemulsion with acidic catalyst. the structure and properties of microemulsion were characterized by transmission electron microscopy (tem), fourier transform infrared spectroscopy (ft-ir), photo correlation spectroscopy (pcs). the effect of the variation in ph value, amoun...