Since each solid form of an active pharmaceutical ingredient (API) can exhibit particular physicochemical properties, the objectives this work were to characterize and study solubility/stability properties allopurinol hydrochloride salt (ALO-HCl) for first time. ALO-HCl was obtained through unreported recrystallization process studied by X-ray powder diffraction (XRD), Fourier transform infrare...

Abstract. Analyzing high-dimensional data poses many challenges due to the “curse of dimensionality”. Not all high-dimensional data exhibit these characteristics because many data sets have correlations, which led to the notion of intrinsic dimensionality. Intrinsic dimensionality describes the local behavior of data on a low-dimensional manifold within the higher dimensional space. We discuss ...

Subject analysis of the potential of spontaneous combustion in coal layers with analytical and numerical methods has been always considered as a difficult task because of the complexity of the coal behavior and the number of factors influencing it. Empirical methods, due to accounting for certain and specific factors, have not accuracy and efficiency for all positions. The Rock Engineering Syst...