conclusions conservative management is successful in the vast majority of patients with spinal headache. interventional procedures are required in a small fraction of patients for symptomatic relief. case presentation intrathecal drug delivery system (idds) was initially used for the management of chronic malignant pain; it has since been used to manage pain from other nonmalignant conditions a...

Rat and mouse were utilized as models to study the spinal (subarachnoid) anesthetic effects of five commonly used local anaesthetic agents. Duration and frequency of motor and sensory blockade, and onset time were determined after injection of 5.0% lignocaine, 0.75% bupivacaine and 1.0% amethocaine to the same groups of rats with chronically implanted catheters in the lumbar subarachnoid space....

background: morphine and lidocaine are known to influence the perception of pain. the present study sought to determine the influence of local administration of morphine on lidocaine-induced analgesia in morphine non-dependent (mnd), morphine dependent (md) and morphine withdrawal (mw) animals. methods: adult male wistar rats were divided into four groups: control, mnd, md and mw rats. lidocain...

among patients with chronic unrelieved pain, war veterans of eight years long iraq - iran war deserve especial attention. they not only suffer from severe intractable pain but also should bear some intangible consequences of unrelieved pain and severe disability. this perspective study reviews the outcome of implantation of intrathecal opioid pumps in these patients. ten war veterans (mean age ...

BACKGROUND Tumescent lidocaine anesthesia consists of subcutaneous injection of relatively large volumes (up to 4 L or more) of dilute lidocaine (≤1 g/L) and epinephrine (≤1 mg/L). Although tumescent lidocaine anesthesia is used for an increasing variety of surgical procedures, the maximum safe dosage is unknown. Our primary aim in this study was to measure serum lidocaine concentrations after ...

INTRODUCTION Endometrial biopsy is necessary for diagnosing the reason of abnormal uterine bleeding in perimenopausal women. Currently outpatient endometrial biopsy is used for evaluation of abnormal uterine bleeding which is associated with moderate to severe pain. Using lidocaine is one of the procedures which is used for pain relief while biopsy. This study is aimed at comparing the effect o...

Objective- To compare the lidocaine-MgSO4 combination with lidocaine-Distilled water inthe epidural of indigenous awake dogs.Design- Prospective experimental study.Animals- Five young (12±2 months) female indigenous dogs weighting (10.74 ± 0.44 kg).Procedures- Epidural anesthesia was produced in all dogs with 2% lidocaine (1ml/4.5 kgbody weight) with 1 ml distilled water and two weeks later rep...

The roles of cytochrome P-450 (CYP) enzymes in the N-deethylation, i.e., formation of monoethylglycinexylidide (MEGX), and 3-hydroxylation of lidocaine were studied with human liver microsomes and recombinant human CYP isoforms. Both CYP1A2 and CYP3A4 were found to be capable of catalyzing the formation of MEGX and 3-OH-lidocaine. Lidocaine N-deethylation by liver microsomes was strongly inhibi...

BACKGROUND Intrathecal opioid administration has been used widely in patients suffering from severe cancer pain that is not managed with conventional modalities. However, the potential serious neurological complications from the procedure and the side effects of intrathecal opioids have made many clinicians reluctant to employ continuous intrathecal analgesia as a first-line therapeutic option ...