the acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. for subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. the intraperitoneal ld50 values of safranal were 1.48 ml/kg in male mice, 1.88 ml/kg in female mice and 1.50 ml/kg in male rats. oral ld50 values were ...

background: toxoplasma gondii is an apicomplexan parasite which infects a broad range of hosts. the classical diagnosis of toxoplasmosis relies on serological methods. detection of parasite or its components could be useful tool for early diag­nosis of the infection. methods: fifty mice were infected by the intraperitoneal route with 5000 tachyzoites of t. gondii rh strain. five of them sacrifi...

Ovarian cancer remains the number one cause of death from gynecological malignancies. Currently, the conventional treatment approach for advanced (stage III and IV) ovarian malignancy is surgical debulking and systemic chemotherapy. Negative second-look laparotomy is attainable in only 20 to 40% of the cases. Up to 47% of these patients relapse within 5 years. In an effort to improve the result...

Because of the short comings conventional anti-inflammatory drugs, researchers have driven their attention towards natural products. Medicinal plants got acknowledged for greatly impacting on health individuals and communities. Spondias mombin is a great species, traditionally used several medicative objectives from ancient times. It has also been popular it’s analgesic effect. In this study, w...

Congenital toxoplasmosis was evaluated in Wistar and Holtzman rats using two strains of Toxoplasma gondii isolated in Brazil. Pregnant rats were inoculated by subcutaneous or intraperitoneal routes with 10(6) or 8 x 10(6) tachyzoites of N strain (virulent for mice) and by subcutaneous or oral routes with 10(2) or 1.2 x 10(3) cysts of P strain (avirulent for mice). The tissues of rat pups born f...

OBJECTIVE To determine effect of route of challenge and strain of rabies virus on efficacy of inactivated rabies vaccines in mice. ANIMALS 3,056 mice. PROCEDURE Challenge was performed with fixed and street rabies virus strains by use of footpad and intracerebral routes as well as IM injection into the hip, shoulder, neck, and masseter muscles. Intraperitoneal and IM vaccination was perform...

The surfaces of the abdomen and pelvis are an important anatomic site for the dissemination of gastrointestinal and gynecologic malignancy. This transcoelomic spread of cancer cells gives rise to peritoneal carcinomatosis which, without special treatments, is a fatal manifestation of these diseases. In order to control peritoneal carcinomatosis cytoreductive surgery to remove gross disease is c...

mouse leukemia to rats ( 12). Cell suspensions from the leukemic tissues of AKR mice were injected by the sub cutaneous, intraperitoneal, or intravenous route into non inbred, newborn Wistar rats. A second inoculation of leukernic cells was given to some groups of rats 7—10days later. Single subcutaneous or intraperitoneal injections did not establish progressively growing, fatal leukemic gra...

Dendritic cells (DC) presenting tumor antigens are crucial to induce potent T cell-mediated anti-tumor immune responses. Therefore DC-based cancer vaccines have been established for therapy, however clinical outcomes are often poor and need improvement. Using a mouse model of B16 melanoma, we found that the route of preventive DC vaccination critically determined tumor control. While repeated D...