Poly-lactide-co-glycolide (PLGA) microparticles emerged as one of the most promising strategies to achieve site-specific drug delivery. Although these microparticles have been demonstrated to be effective in several wound healing models, their potential in cardiac regeneration has not yet been fully assessed. The present work sought to explore PLGA microparticles as cardiac drug delivery system...

This study aimed to investigate the cardioprotective effects of intramyocardial injection of heart derived extracellular matrix (ECM) and cardiosphere-derived cells (CDCs) in a rat model of myocardial infarction (MI). ECM and CDCs were collected from the rat heart, and the proliferation, apoptosis and morphology of CDCs maintained on ECM were characterized in vitro. MI model was established in ...

BACKGROUND In an experimental model in the rabbit, a myocardial ischemia-reperfusion injury was obtained. Subsequently, the effects of homologous bone marrow stem cell (BMSC) administration were studied. METHODS In 21 New Zealand adult rabbits, ischemia/reperfusion damage was induced by temporary occlusion of the anterior descending coronary artery. Homologous BMSCs were isolated, cultured an...

We describe a rare case of a 60-year-old woman suffering from intramyocardial dissection and left ventricular aneurysm secondary to acute myocardial infarction. A rare form of ventricular septal rupture resulted from intramyocardial dissection deterioration, which was identified during echocardiographic follow-up. Surgical repair under beating-heart cardiopulmonary bypass was successful.

Growth differentiation factor 11 (GDF11) is a member of the transforming growth β superfamily that alleviates cardiac hypertrophy, myocardial infarction, and vascular injury by regulating oxidative stress, inflammation, cell survival. However, roles underlying mechanisms GDF11 in diabetic cardiomyopathy (DCM) remain largely unknown. In this study, we sought to determine whether could prevent DC...

In the controversy about the mechanisms determining the high zero flow pressures and the further interpretation of coronary diastolic pressure flow relations, this paper takes a stand in favor of intramyocardial compliance as the primary cause of the high zero flow pressures. An attempt has been made to estimate the compliance distribution within the coronary circulation and to show the specifi...