BACKGROUND AND PURPOSE We sought to test the hypothesis that intra-arterial recombinant tissue plasminogen activator (rtPA) treatment of thromboembolic stroke is more efficient than intravenous application. METHODS Rats were embolized by intracarotid injection of autologous fibrin-rich blood clots. One hour later rtPA (10 mg/kg) was infused either intravenously (n=8) or intra-arterially (n=8)...

background: the use of assisted reproductive technology (art) is increasing in the world. the rate, efficacy and safety of art are very different among countries. there is an increase in the use of intra cytoplasmic sperm injection (icsi), single fresh embryo transfer (et) and frozen-thawed embryo transfer (fet). objective: the objective of this study was to compare pregnancy rate in fresh et a...

BACKGROUND Lithium, a mood stabilizer, may exert adverse effects on memory. We have previously shown that lithium induces state-dependent learning. Cholinergic systems of the brain may play an important role in memory function and mood regulation. In the present study, the effects of intra-dorsal hippocampal (intra-CA1) injections of lithium and scopolamine on memory and cross state-dependent l...

CONTEXT Corticosteroid is a well-established cause of drug-induced pancreatitis. However, acute pancreatitis from intra-articular injection of corticosteroid has never been described. CASE REPORT A 69-year-old male presented with acute abdominal pain and was diagnosed with acute pancreatitis. The patient had one episode of acute pancreatitis two year earlier. Both episodes occurred after intr...

BACKGROUND Iosimenol 340 injection is a new, dimeric, iso-osmolar, iodinated contrast medium for X-ray angiography. PURPOSE To compare the safety and efficacy of iosimenol injection to iodixanol injection in two randomized, controlled phase 2 trials. MATERIAL AND METHODS One hundred and forty-four adult patients were enrolled in the two trials, one for evaluation during arteriography and th...

introduction intra-articular injections of platelet rich plasma (prp) for the treatment of knee osteoarthritis have been shown to reduce pain and improve joint function. the aim of this study is to examine the joint function by adding intra-articular growth hormone to platelet rich plasma. this study was performed on the individuals with knee osteoarthritis and under ultrasound guidance. conclu...

The activity of angiotensin-converting enzyme in hindlegs and kidneys was compared in anesthetized dogs. Intra-arterial injections of angiotensin I or angiotensin II to one kidney or one hindleg caused dose-dependent decreases in blood flow in that vascular bed. An inhibitor of angiotensin-converting enzyme activity did not affect the vasoconstrictor activity of angiotensin II but substantially...

Pre-operative embolisation of vertebral metastases has been known to effectively devascularise hypervascular vertebral tumours and to reduce intra-operative bleeding. However, the complications that occur during the procedure are rarely reported. This case study attempts to highlight one rare complication, which is epidural tumoural haemorrhage intra-procedure. It may occur due to the fragility...

THE treatment of cancer by the local application of chemical substances has been practised since the time of Hippocrates. Moore, writing in the British Medical Journal of 1866, commented on the failure of occasional applications of caustic pastes in the treatment of cancer and suggested the necessity for a long continued stream of the medicinal agent flowing through the tumour. Modern chemother...

BACKGROUND AND PURPOSE Intra-arterial chemotherapy is a very effective treatment option for intraocular retinoblastoma. However, direct catheterization of the OA is not always possible. The purpose of this work was to report our initial results with intra-arterial chemotherapy for intraocular retinoblastoma when delivery of the drug was not via direct catheterization of the OA. MATERIALS AND ...