objective: duplex ultrasonography is a non-invasive, non-expensive screening test for carotid disease. intima media thickness (imt) is appropriate for atherosclerosis process diagnosis. leukoaraisis (la) increase the risk of cerebrovascular accident (cva). la patients need preventive medication for cva. imt is a non-invasive diagnostic and prognostic test in la. the aim of this study was evalua...

Endothelin-1 is a potent vasoconstrictor produced by vascular endothelial cells. A recently cloned endothelin-1-selective receptor, the endothelin-A receptor, mediates the vasoconstrictive action of endothelin-1. Because endothelin-1 also possesses mitogenic properties, it may play a role in regulating the proliferation of intimal smooth muscle cells. In this study, we analyzed the expression o...

objective: atherosclerosis disease, inflammation and malnutrition have strong association with end stage renal disease (esrd). diabetes mellitus (dm) is the most commonly esrd causes. diabetic nephropathy (dn) could be associated with inflammation. type 2 diabetic patients with advanced nephropathy show the highest levels of inflammatory markers. this study was designed to determine the associa...

A 40-year-old man was admitted to our hospital for chest pain after smoking. Coronary computed tomography angiography showed severe stenosis in the left anterior descending artery. The stenosis site had no plaque on stretched curved multiplanar reconstruction and short-axis images. Coronary angiography revealed improvement of the severe stenosis after the intracoronary administration of isosorb...

Introduction Hypertension puts continuous strain on arteries, resulting in arterial wall alterations such as vessel wall thickening and vessel wall stiffening. Due to the availability of suitable acoustic windows, vessel wall thickness (VWT) is studied traditionally by ultrasound from intima-media thickness in the carotid arteries. Arterial vessel wall stiffness can be expressed by Pulse Wave V...

an occlusive, diffuse, generalized lesion in medium and small-sized arteries, with particular involvement of the heart, skin, gastrointestinal tract, kidneys, pancreas, and liver. It showed a fibrous thickening of the intima; the internal lamina elastica, the media, and the adventitia remained unchanged. A pathogenic interpretation of the vascular lesions is attempted, and their asynchronism in...

BACKGROUND A precise understanding of the mechanism of human neointimal stenoses and atherosclerotic fibrous plaques, which give rise to thromboses in vital arteries, requires a suitable animal model that would mimic the same characteristics well. We developed a rabbit model of neointimal stenosis and fibrotic plaque rupture in the carotid artery to visualize the lesion progress and to characte...

BACKGROUND The thickness of the arterial intima increases and that of the media decreases with increasing age and degree of atherosclerosis. Separate estimates of the individual intima and media layers might therefore be more appropriate than the commonly used method estimating the combined intima-media thickness (IMT). METHODS AND RESULTS One hundred consecutive 70-year-old subjects from the...

Briefly, based on the previous evidence and the results of the present study, it seems that infection with HTLV-1 by destruction of sub-layers of arteries, especially the intima layer, leads to disruption of the integrity of sub-layers of arteries and through various mechanisms, causing the sub-layer’s destruction, increasing the intima-media thickness, changing the lipid profile, and developme...