The drop in the MRI signal intensity, analysed without any normalisation, was found related to the intervertebral disc degeneration, but its association with low back pain remains controversial. The authors developed the analysis of MR signal intensity distribution (AMRSID) method that analyzes the 3D distribution of the normalized T2-weighted MR signal intensity within the intervertebral disc ...

PURPOSE To quantify the delayed contrast agent enhancement in the nucleus pulposus of the intervertebral disc by means by T1 relaxation time measurements, and to correlate the enhancement with visual grading of disc degeneration. Diffusion of nutrients through the endplate is a key factor in tissue viability in the intervertebral disc. It can be simulated in vivo using magnetic resonance imagin...

Degeneration of the intervertebral discs, a process characterized by a cascade of cellular, biochemical, structural and functional changes, is strongly implicated as a cause of low back pain. Current treatment strategies for disc degeneration typically address the symptoms of low back pain without treating the underlying cause or restoring mechanical function. A more in-depth understanding of d...

STUDY DESIGN In vitro cell culture. PURPOSE The purpose of this study was to investigate the effect of high glucose on autophagy in adult rat intervertebral disc cells. OVERVIEW OF LITERATURE Diabetes mellitus is considered to be an important etiologic factor for intervertebral disc degeneration, resulting in degenerative disc diseases. A glucose-mediated increase of autophagy is a major ca...

Introduction: Internal derangement (ID) of TMJ is the most common type of temporomandibular disorders after muscle disorders and includes all disorders related to incoordination and dislocation of disc and condyle. Anterior disc displacement without reduction or closed lock will happen if the disc or condyle displaces severely or if the disc traps in the space in front of the condyle accompanie...

Lumbar disc herniation (LDH) is the most common lumbar spinal disorder that produces low back pain and/or leg pain. A herniated a displacement of material (nucleus pulposus or annulus fibrosis) beyond intervertebral space. LDH may be correlated with Katigraha in Ayurveda on basis clinical features disease where Vatadosha without Aamadosha settles Katipradesh (lumbar region). and cause stiffness...

Schmorl nodes represent displacement of intervertebral disc tissue into the vertebral body and have been considered as an asymptomatic incidental radiological finding on plain radiographs, computed tomography and magnetic resonance imaging (MRI). Although uncommon, acute symptomatic Schmorl nodes causing severe back pain do occur. We report here an unusual case of acute painful Schmorl node in ...

Dear editor: We present two cases of high signal intervetebral disc in T1-weighted MRI with the differential diagnoses. The first case was a 60-year-old obese man who presented with back pain. The patient underwent an MR examination with a 0.3T permanent scanner (Hitachi, IRIS-II Japan). Spin–echo T1W, T2W images in orthogonal planes and STIR sequences were also obtained (Fig. 1). Hypersignal i...

Rationale There is no optimal treatment available for symptomatic degenerative disc disease which affects millions of elderly people worldwide. Most commonly used treatment modality is only symptomatic pain relief by drugs. An alternative approach is the surgical correction of intervertebral disc (IVD). Engineering of in vitro intervertebral disc composites of predefined size and shape starting...