4'-Demethoxydaunorubicin (idarubicin [IDR]) is a new anthracycline that differs from its parent compound by the deletion of a methoxy group at position 4 of the chromophore ring. This minor structural modification results in a more lipophilic compound with a unique metabolite that has a prolonged plasma half-life as well as in vitro and in vivo antileukemia activity. To determine its activity i...

An integrated seismic monitoring system with a total of 55 channels of accelerometers is now operating at and in the nearby free-field site of the 20-story steel-framed Atwood Building, in highly seismic Anchorage, Alaska. The building has a single-story basement and a reinforced-concrete foundation without piles. The monitoring system comprises a 32-channel structural and a 21channel site arra...

OBJECTIVE To determine the risk of concussion among youth football players (ages 8-12 years). STUDY DESIGN Participants included 468 male youth football players in western Pennsylvania during the 2011 youth football season. Incidence rates (IRs) and incidence density ratios (IDRs) of concussion were calculated for games and practices and for age groups. RESULTS There was a total of 11,338 (...

Alternative splicing (AS) is known to significantly affect exon-level protein evolutionary rates in mammals. Particularly, alternatively spliced exons (ASEs) have a higher nonsynonymous-to-synonymous substitution rate (dN/dS) ratio than constitutively spliced exons (CSEs), possibly because the former are required only occasionally for normal biological functions. Meanwhile, intrinsically disord...

This work applies 64,765 simulated seismic ground motions to four models each of 6or 20-story, steel special moment-resisting frame buildings. We consider two vector intensity measures and categorize the building response as “collapsed,” “unrepairable,” or “repairable.” We then propose regression models to predict the building responses from the intensity measures. The best models for “collapse...

Six-degree-of-freedom (6DoF) sensors measure translation along three axes and rotation around axes. These collocated measurements make it possible to fully describe building motion without the need for an external reference point. This is advantage health monitoring, which uses interstory drift eigenfrequencies monitor stability. In this paper, IMU50 6DoF are characterized determine their suita...

Welcome to the new online-only, international, Open Access, peer-reviewed journal, Infectious Disease Reports (IDR). It is a profound honor to lead this new journal, and I would like to share with you my vision for IDR and take this opportunity to encourage you to submit your work for peer review. It is a great challenge to define the scope of a new infectious disease journal given the wide bre...

The ImmunoDeficiency Resource (IDR), freely available at http://www.uta.fi/imt/bioinfo/idr/, is a comprehensive knowledge base on immunodeficiencies. It is designed for different user groups such as researchers, physicians and nurses as well as patients and their families and the general public. Information on immunodeficiencies is stored as fact files, which are disease- and gene-based informa...

The induced dimension reduction (IDR) method, which has been introduced as a transpose-free Krylov space method for solving nonsymmetric linear systems, can also be used to determine approximate eigenvalues of a matrix or operator. The IDR residual polynomials are the products of a residual polynomial constructed by successively appending linear smoothing factors and the residual polynomials of...

Abstract This study addresses the effectiveness of buckling restrained braces (BRBs) and viscous dampers (VDs) in dissipating seismic energy increasing performance irregular composite buildings during earthquake events. The response steel-concrete moment resisting frames 15 stories with concrete filled steel tubes (CFST) as columns beams was examined without protection devices by employing ETAB...