BACKGROUND Intermittent claudication is associated with significant impairment of health-related quality of life. The use of revascularization techniques to improve health-related quality of life remains controversial. METHODS Patients with intermittent claudication due to iliac or femoropopliteal peripheral artery disease were enrolled in the IRONIC trial. They were randomized to either best...

Electronic search of the MEDLINE, CINAHL, and Cochrane Library databases. We examined 27 studies (12 randomized, 15 nonrandomized) reporting home-based exercise programs for intermittent claudication documented four (0.2%) related adverse events in 1642 participants (two-thirds male). Three these were cardiac origin all occurred without screening. Based on low number events, seem to be a safe m...

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Objective—Reduced limb perfusion from arterial stenosis does not adequately account for intermittent claudication symptoms in peripheral artery disease (PAD). Insulin resistance is associated with PAD and may contribute to claudication by impairing skeletal muscle metabolism. We aimed to determine whether skeletal muscle glucose uptake, assessed by [F]fluorodeoxyglucose positron emission tomogr...

Vitamin E for Intermittent Claudication Thirty-three patients with moderately severe intermittent claudication (mean duration of symptoms, two years) received 400 IU per day of vitamin E or placebo for 3 months. The mean walking distance before onset of pain increased to a significantly greater extent in the vitamin E group than in the placebo group (1487o vs. 31%; p < 0.01 for the difference i...

Adventitial cystic disease is a rare non-atherosclerotic vascular disease. We report a 36-year-old man with right intermittent claudication by adventitial cystic disease. computed tomography (CT) and magnetic resonance imaging (MRI) revealed an ovoid cystic mass compressing the right popliteal artery and causing severe stenosis of the lumen. Percutaneous aspiration was performed, which improved...

BACKGROUND Peripheral arterial disease (PAD) has a population prevalence of 4.6% with intermittent claudication (IC) presenting as one of the earliest and most common symptoms. PAD has detrimental effects on patients' walking ability in terms of maximum walking distance (MWD) and pain-free walking distance (PFWD). Research has suggested extracorporeal shockwave therapy (ESWT) may induce angioge...