نتایج جستجو برای: intermediate thalassemia

تعداد نتایج: 151460  

Journal: :Genes & genetic systems 2009
Jin Ai Mary Anne Tan Juan Loong Kok Kim Lian Tan Yong Chui Wee Elizabeth George

Co-inheritance of alpha-thalassemia with homozygosity or compound heterozygosity for beta-thalassemia may ameliorate beta-thalassemia major. A wide range of clinical phenotypes is produced depending on the number of alpha-thalassemia alleles (-alpha/alphaalpha --/alphaalpha, --/-alpha). The co-inheritance of beta-thalassemia with alpha-thalassemia with a single gene deletion (-alpha/alphaalpha)...

2015
Fatemeh Behdani Zahra Badiee Paria Hebrani Fatemeh Moharreri Amir Hossein Badiee Negin Hajivosugh Zohreh Rostami Amir Akhavanrezayat

BACKGROUND Thalassemia is an inherited blood disease. It is a serious public health problem throughout the Mediterranean region, the Middle East and the Indian subcontinent, as well as in Southeast Asia. OBJECTIVES Thalassemia is an inherited blood disease. It is a serious public health problem. In this study we assessed psychological aspects in Iranian children and adolescents with thalassem...

Journal: :Pediatric blood & cancer 2009
Mehran Karimi Rahil Giti Sezaneh Haghpanah Azita Azarkeivan Hamid Hoofar Masoomeh Eslami

BACKGROUND Beta thalassemia is one of the most common genetic disorders in the world. The aim of this study was to determine the frequency, characteristics, and pattern of malignancies in patients with beta thalassemia major (BTM) and beta thalassemia intermedia (BTI) in Iran. METHODS We conducted a multicenter study via a retrospective chart review of patients with BTM and BTI between 2002 a...

2012
Hossein Safizadeh Zahra Farahmandinia Simin Soltani nejad Nasim Pourdamghan Majid Araste

Thalassemia is the most common hemoglobin disorder in the world and thalassemia major and intermedia stand among the most severe forms. Due to recent improvements in treatment, patients with thalassemia have longer life expectancies; hence it is of utmost importance to pay careful attention to their quality of life together with life expectancy. This study was conducted to assess the quality of...

Journal: :Blood 1998
D C Rees J B Clegg D J Weatherall

Hemoglobin E (HbE; alpha2beta226glu-lys), globally the commonest hemoglobin variant, is synthesized at a slightly reduced rate and has a homozygous phenotype similar to heterozygous beta thalassemia. Yet, when it is inherited together with a beta thalassemia allele, the resulting condition, HbE/beta thalassemia, is sometimes characterized by a severe, transfusion-dependent thalassemia major. Th...

Journal: :International Journal of Research in Medical Sciences 2021

Thalassemia is a heterogeneous group of genetic disorder with the defective synthesis one or more globin chains. β-thalassemia global disease high prevalence in Africa, Southeast Asia and Mediterranean countries. In Malaysia, α are commonest. articles that we reviewed, transfusion-dependent highly associated complications related to thalassemia such as cardiovascular disease, endocrine disorder...

Journal: :Blood 1977
H I Pierce S Kurachi K Sofroniadou G Stamatoyannopoulos

The frequency of thalassemia was determined in a group of 541 healthy adult black males. Individuals with decreased mean corpuscular hemoglobin (MCH) values were evaluated further with hemoglobin analysis, iron studies, and globin chain synthesis. Of the males screened, 13.4% had MCH levels below 27.0 pg, while 1.4% had heterozygous beta thalassemia, 2.3% had iron deficiency, and 5.7% had globi...

2006
Pimlak Charoenkwan Chanane Wanapirak Pattra Thanarattanakorn Rattanaporn Sekararithi Rattika Sae-Tung Somjai Sittipreechacharn Torpong Sanguansermsri

Coinheritance of α-thalassemia and hemoglobin E (Hb E) is prevalent in Thailand, where the gene frequencies of thalassemia and hemoglobinopathies are high. Hb E carriers with, concomitant inheritance of α-thalassemia 1 are known to have a lower level of Hb E. In this study, we reviewed the Hb E levels in Hb E carriers, who either had or did not have Southeast Asian (SEA)-type α-thalassemia, in ...

Journal: :Clinical chemistry and laboratory medicine 2009
Paolo Danise Giovanni Amendola Rosanna Di Concilio Enrico Cillari Maria Gioia Anna Di Palma Daniela Avino Paolo Rigano Aurelio Maggio

BACKGROUND The technology to recognize nucleated red blood cells (NRBC) automatically has only recently been developed. Modern hematology analyzers allow for rapid and accurate NRBC counts. The goal of our study was to evaluate NRBC counts and the concentrations of serum transferrin receptor (sTfR) in patients affected by different thalassemia syndromes and hereditary spherocytosis. We wished t...

2017
Sehjeong Kim Abdessamad Tridane

Thalassemia is a genetic blood disorder that causes abnormal hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen and is made of two proteins from four α-globin genes and two β-globin genes. A defect in one or more of these genes causes thalassemia. The treatment of thalassemia mostly depends on life-long blood transfusions and removal of excessive iron from the blood stre...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید