background: this study was performed to compare the effects of low dose interferon beta-1 (ifn-β-1) (cinnovex, 30 mcg) and high dose ifn-β-1 (rebif, 44 mcg) on the reduction of the number and size of plaques in magnetic resonance imaging (mri) in patients with multiple sclerosis (ms). methods: this historical cohort study, which was performed in 2014 in sanandaj (western part of iran). 43 ms pa...

background hemangiomas, usually, present at the first few hemangiomas, usually, present at the first few months of life and are the most common benign tumor in children. there are various therapeutic methods for hemangioma. capillary hemangioma is a type of hemangiomas. the steps of treatment of a child with capillary hemangioma in taleghani hospital of gorgan, iran, are reported. case report i...

conclusions treatment with peg ifn α achieved a sustained negativity of hdv rna in about one third of patients. duration of peg ifn α therapy might be prolonged to at least 24 months or more to prevent the occurrence of hepatitis b virus (hbv) relapse encountered six months after completion of the treatment. patients and methods the sample size was based on available patients potentially to be ...

background: brucella is a gram-negative bacterium, causing acute and chronic infection in humans and animals. cell-mediated immunity is the main protective immune response against brucella spp. activation of macrophages by ifn-γ and generation of reactive oxygen intermediates and nitric oxide are the main immunologic mechanisms responsible for control of brucella infection. objective: to invest...

background polymorphisms in the interferon λ (inf λ) genes on chromosome 19 have been associated with clearance of hepatitis c virus (hcv) induced by interferon and ribavirin therapy however there is no such data available for pakistani patients with hcv infection. objectives in this study, the effects of single nucleotide polymorphisms (snps) have been investigated in response to treatment wit...

Human Interferon β (INF-β) is a member of cytokines family which different studies have shown its immunomodulatory and antiviral activities. In this study an expression vector was designed and constructed for expression of human INF-β-1b either in shake flasks and bench top bioreactor. The designed vector was constructed based upon pET-25b(+) with T7 promoter. Recombinant human beta interferon ...

Background and Aims: Iron oxide nanoparticles are among the most effective tools which can replace current medical techniques for diagnosis and treatment of various diseases. Hepatitis C infection is one of the main health problems in the world, affecting around 3% of the world's population. This infection can develop into liver cirrhosis and liver cancer over the time in 80% of patients. In t...

introduction patients with hepatitis c are commonly treated with combination of pegylated interferon alfa-2a and ribavirin. less than 1% of patients receiving this treatment experience very uncommon ophthalmological side effects such as optic neuropathy and vision disorder, which are usually subclinical, mild and reversible, not requiring the withdrawal of the treatment. retinopathy is the most...