Bangladesh is dominated by a small-holder agrarian economy under extreme stress. Production shortfalls, increasing economic polarization, and chronic malnutrition are persistent, but major famine has been diverted in part by significant growth in agriculture. This recent history is open to both Malthusian and Boserupian interpretations-a history we explore here through a test of the induced int...

OBJECTIVE Although suboptimal glycemic control is known to be common in diabetic adults, few studies have evaluated factors at the level of the physician-patient encounter. Our objective was to identify novel visit-based factors associated with intensification of oral diabetes medications in diabetic adults. RESEARCH DESIGN AND METHODS We conducted a nonconcurrent prospective cohort study of ...

Future changes in North Pacific wintertime climate will be largely determined by the response of the Aleutian Low (ALow) pressure system to anthropogenic forcing. Although the ALow has intensified over the twentieth century, global climate model projections of future ALow variability are equivocal. In order to evaluate decadal to centennial ALow forcing mechanisms and provide context for the mo...

Losses of biodiversity and ecosystem functioning due to rainforest destruction and agricultural intensification are prime concerns for science and society alike. Potentially, ecosystems show nonlinear responses to land-use intensification that would open management options with limited ecological losses but satisfying economic gains. However, multidisciplinary studies to quantify ecological los...

Asparaginase is an expensive drug, but important in childhood acute lymphoblastic leukemia. In order to compare costs of PEGasparaginase, Erwinia asparaginase and native E. coli asparaginase, we performed a cost-analysis in the Dutch Childhood Oncology Group ALL-10 medium-risk group intensification protocol. Treatment costs were calculated based on patient level data of 84 subjects, and were re...

Food production is a major driver of global environmental change and the overshoot of planetary sustainability boundaries. Greater affluence in developing nations and human population growth are also increasing demand for all foods, and for animal proteins in particular. Consequently, a growing body of literature calls for the sustainable intensification of food production, broadly defined as "...

[1] Using International Best Track Archive for Climate Stewardship (IBTrACS, version v03r03) analysis during satellite era (1986–2010) we determined the trends of intensification of tropical cyclones (TC) over all the global basins, except the North Indian Ocean. Over all the basins, the rate of TC intensification from 64 kt to first peak of intensity maxima (global average value = 104 kt) was ...

Worldwide, human appropriation of ecosystems is disrupting plant-pollinator communities and pollination function through habitat conversion and landscape homogenisation. Conversion to agriculture is destroying and degrading semi-natural ecosystems while conventional land-use intensification (e.g. industrial management of large-scale monocultures with high chemical inputs) homogenises landscape ...