When administering eye drops, even when completely correctly applied, several routes of absorption are possible and excess amounts can sometimes cause an unwanted systemic bioavailability of the drops when not completely absorbed into the eye. Furthermore, the concentration of active ingredients in such medicinal preparations is usually very high, so that despite the correct application of the ...

The quality, size, and number of protein crystals grown under conditions of continuous solvent extraction are dependent on the rate of solvent extraction and the initial protein and salt concentration. An increase in the rate of solvent extraction leads to a larger number of crystals. The number of crystals decreases, however, when the experiment is started with an initial protein concentration...

We study the watersheds in edge-weighted graphs. Contrarily to previous works, we define the watersheds following the intuitive idea of drops of water flowing on a topographic surface. We establish the consistency (with respect to characterizations of the catchment basins and dividing lines) of these watersheds, prove their optimality (in terms of minimum spanning forests) and derive a linear-t...

In order to overcome the defects of the slow convergence rate of the traditional Genetic Algorithm and basic Particle Swarm Optimization drops into local optimum easily, an improved Particle Swarm Optimization algorithm based on hybrid algorithm is proposed and applied to the signal detection for MIMO-OFDM system. The algorithm optimizes the basic Particle Swarm Optimization algorithm and some ...

The aim of this paper is to review the key findings about how particle-stabilised (or Pickering) emulsions respond to stress and break down. Over the last ten years, new insights have been gained into how particles attached to droplet (and bubble) surfaces alter the destabilisation mechanisms in emulsions. The conditions under which chemical demulsifiers displace, or detach, particles from the ...

Radar observations of the ocean surface can be affected by impacting raindrops. Ring-wave measurements are presented for drops of 2.2 and 2.8 mm in diameter impacting on fresh and salt water surfaces initially at rest. They are based on the observation of the mirror image of a sharp edge on the perturbed surface. The retrieved wave profiles show a rather stable characteristic wavenumber (0.2 mm...

Studies on environmental changes provide important insights into modes of speciation, into the (adaptive) reoccupation of ecological niches and into species turnover. Against this background, we here examine the history of the gastropod genus Lanistes in the African Rift Lake Malawi, guided by four general evolutionary scenarios, and compare it with patterns reported from other endemic Malawian...

BACKGROUND Orthostatic hypotension (OH) is very common, particularly in older populations. Diagnostic criteria exist but appear to be arbitrary rather than evidence based. This review will visit the evidence for diagnostic strategies for OH. DATA SOURCES Medline (OvidSP), EMBASE (OvidSP), ISI Web of Science, the Health Technology Assessments Database and the Cochrane Library. AREAS OF AGREE...

Introduction Although the local adverse effects of ophthalmic drugs, including allergic reactions, are well recognized, less is known about the systemic side- effects of eye drops, especially during pregnancy, breast-feeding and early childhood. Ophthalmologists should also be aware of unusual, in some cases even life-threatening, effects of commonly used eye drops. Conclusion This brief revi...