In a previous study, the administration of a grape seed procyanidin extract (GSPE) in female Wistar rats improved insulin resistance, reduced insulin production, and modulated apoptosis biomarkers in the pancreas. Considering that pharmacokinetic and pharmacodynamic parameters in females are different from these parameters in males, the aim of the present study was to evaluate the effects of GS...

Diabetes mellitus is a group of metabolic diseases. Insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. Several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. Adiponectin as a 244 amino acid protein is exclusively expressed...

conclusions because of increasing prevalence of prediabetes at earlier age, it seems necessary to reconsider the screening age in urban areas and perform the screening in all adults at younger ages. results the prevalence of diabetes was 7.04% (4.52% women, 2.52% men) and the prevalence of prediabetes was 8.58% (5.59% women, 2.98% men). thehighest prevalence of diabetes and prediabetes were obs...

rabson-mendenhall syndrome is a rare genetic disorder characterized by growth retardation, dysmorphisms, lack of subcutaneous fat, acanthosis nigricans, enlarged genitalia, hirsutism, dysplastic dentition, coarse facial features, paradoxical fasting hypoglycemia, postprandial hyperglycemia, extreme hyperinsulinemia and pineal hyperplasia. herein, we described a 10- year-old girl with physical f...

background: polycystic ovarian syndrome (pcos) is a common disease among women in fertility ages and cause severe insulin resistance. hyperhomocysteinaemia is said to be among the features of pcos that could influence its outcome. objective: this study aimed to investigate whether hyperhomocysteinaemia exists in pcos and if it is related to insulin resistance in the affected patients. materials...

objectives: to investigate fasting glucose, glucose tolerance, insulin resistance and insulin–like growth factor 1 in patients with or without colorectal polyps. materials and methods: in this cross-sectional study, we evaluated fasting glucose, insulin, insulin–like growth factor 1 (igf-1), lipid profile and glucose tolerance test in 103 patients undergoing colonoscopy (52 normal and 53 with a...

Background This study compared the contents of extracts Chenopodium formosanum (Djulis) originating from 2 aboriginal areas (Kaohsiung and Taitung, Taiwan) evaluated their efficacy in ameliorating insulin resistance vitro. Methods First, we analyzed anti-oxidant compositions activity, α-glucosidase, α-amylase inhibitory effects Djulis extracts, then ability to ameliorate HepG2 cell. To do this,...

Berberine-containing herbs such as golden seal (Hydrastis canadensis) and barberry (Berberis vulgaris) are traditionally said to be contraindicated in pregnancy. The British Herbal Pharmacopoeia 1983 is one such source of this information. In most earlier texts or articles it is not always clear as to why this contraindication might exist. Certainly in the case of golden seal the concern was th...

ABSTRACT Physical activity is known to influence and regulate leptin hormone secretion, which assists in the regulation of body weight and energy homeostasis. The purpose of the present study was to investigate the effects of a single session of concurrent exercise on leptin levels and insulin resistance, until 24 h post-exercise. Ten male subjects (22.9±1.7 years) healthy volunteer perf...