نتایج جستجو برای: inotropic

تعداد نتایج: 5240  

Journal: :Circulation research 1994
R D Minshall V P Yelamanchi A Djokovic D J Miletich E G Erdös S F Rabito S M Vogel

Isolated rat left atria or right ventricular strips were electrically stimulated at a constant frequency. The amplitude of twitch contractions, thus elicited, rose as a function of stimulation intensity because of increases in the evoked release of sympathetic catecholamines. Bradykinin had no effect on contractile force in preparations paced at a minimal intensity (threshold). By contrast, bra...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
Alejandro N Mazzadi Marc F Janier Benjamin Brossier Xavier André-Fouët Didier Revel Pierre Croisille

In severe coronary artery disease (CAD), it has been shown that intramyocardial inotropic reserve as assessed with tagged magnetic resonance imaging (MRI) is uniformly distributed among positron emission tomography (PET) patterns reflecting normal or concomitant reductions in perfusion and glucose metabolism. This preliminary study aimed to delineate the relationship between preoperative values...

Journal: :Circulation research 2003
Dirk von Lewinski Kerstin Voss Swen Hülsmann Harald Kögler Burkert Pieske

Myocardial generation of insulin-like growth factor-1 (IGF-1) is altered in hypertrophy and heart failure, but there are no reports on acute functional effects of IGF-1 in human cardiac muscle. We examined inotropic responses and signal transduction mechanisms of IGF-1 in human myocardium. Experiments were performed in isolated trabeculae or cardiomyocytes from 46 end-stage failing hearts. The ...

2002
Haibin Gong Walter J. Koch Thomas Eschenhagen Dawn L. Adamson Sian E. Harding

Background—We have observed direct (noncatecholamine-blocking) negative inotropic effects of the selective 2adrenoceptor (AR) antagonist ICI 118,551 in myocytes from failing human ventricle. In this study we characterize the effect in parallel in human myocytes and in myocytes from animal models where 2ARs or Gi proteins are overexpressed. Methods and Results—Enzymatically isolated, superfused ...

Journal: :American journal of physiology. Cell physiology 2008
Fabien A Faucher François E Gannier Jacques M Lignon Pierre Cosnay Claire O Malécot

Although beta(2)-adrenoceptors represent 15-25% of beta-adrenoceptors in the guinea pig heart, their functionality is controversial. We assessed the inotropic effects of beta(2)-adrenoceptor partial agonists in right papillary muscles. Salbutamol induced a small but significant concentration-dependent negative inotropic effect (NIE, -5% at 60 nM) followed by a moderate positive inotropic effect...

2015
Makiko Sugiura Chieko Mitaka Go Haraguchi Makoto Tomita Naohiko Inase

BACKGROUND Polymyxin B-immobilized fiber column hemoperfusion (PMX) has been reported to be effective for patients with septic shock. It remains unclear, however, how the efficacy of PMX varies according to the characteristics and underlying conditions of the patients treated. The objective of the present study was to clarify the factors that result in clinical efficacy of PMX treatment. METH...

2007
Jefferson High

Study objectives: This study was conducted to assess cost savings and clinical outcomes associated with the use of home IV inotropic therapy in patients with advanced (New York Heart Association [NYHA] class IV) heart failure. Design: Retrospective analysis. Setting: Tertiary care referral center. Patients and interventions: Twenty-four patients (13 men, 11 women; age, 61 ±12 years) with left v...

2017
Jae Moon Choi Jun-Young Jo Jae-Won Baik Sooyoung Kim Chan Sik Kim Sung-Moon Jeong

Preservation of adequate perfusion pressures to the graft is a main focus of intraoperative management during kidney transplantation. We undertook this study to investigate the incidence of the higher use of inotropes in kidney transplant recipients and identify the patient outcomes and preoperative and intraoperative variables related to this.We retrospectively analyzed 1053 patients who under...

Journal: :European journal of heart failure 2002
Simon Thackray Joanne Easthaugh Nick Freemantle John G F Cleland

AIMS To review systematically the use of intravenous (IV) inotropic agents acting through the adrenergic signalling pathway, compared with placebo or an active agent, in patients with heart failure. METHODS Studies investigating the use of intravenous inotropes in patients with heart failure published between 1966 and 2000 were identified using MEDLINE, the Cochrane register and Embase databa...

Journal: :iranian journal of toxicology 0
رضا بدل زاده reza badalzadeh department of physiology and biophysics, medical faculty, baqiyatallah university of medical sciences,tehran-iran علی نوروز زاده ali norouzzadeh department of physiology and biophysics, medical faculty, baqiyatallah university of medical sciences,tehran-iran مصطفی محمدی mustafa mohammadi department of physiology and biophysics, medical faculty, baqiyatallah university of medical sciences,tehran-iran علیرضا عسگری alireza asgari department of physiology and biophysics, medical faculty, baqiyatallah university of medical sciences,tehran-iran علی خوش باطن ali khoshbaten department of physiology and biophysics, medical faculty, baqiyatallah university of medical sciences,tehran-iran

background: there are controversial reports about the exact mechanisms of lead-induced hypertension, but many factors such as alteration in the responsiveness of cardiovascular system to endogenous substances including catecholamines could be one of the mechanisms involved. in present study, the effect of exposure to 100 ppm lead acetate by drinking water (in the periods of 4, 8 and 12 weeks) o...

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