MicroRNA-200 family members are expressed in the developing mouse inner ear and in zebrafish (Danio rerio) olfactory epithelia, taste buds, and neuromasts, and have also been shown to be associated with differentiation of olfactory and taste buds. However, the role of the miR-200 family in the inner ear of zebrafish had not been studied. We investigated the expression and function of the miR-20...

Autophagy is a conserved catabolic process that results in the lysosomal degradation of cell components. During development, autophagy is associated with tissue and organ remodeling, and under physiological conditions it is tightly regulated as it plays a housekeeping role in removing misfolded proteins and damaged organelles. The vertebrate inner ear is a complex sensory organ responsible for ...

The middle ear infection is the most common childhood infection. In order to elucidate the cell and molecular mechanisms involved in bacterial recognition and innate immune response, we have established a stable human middle ear cell line, which has contributed to the current knowledge concerning the molecular pathogenesis of the middle ear infection. The inner ear, a sensory organ responsible ...

introduction:visualization of inner ear structures is a valuable strategy for researchers and clinicians working on hearing pathologies. optical coherence tomography (oct) is a high-resolution imaging technology which may be used for the visualization of tissues. in this experimental study we aimed to evaluate inner ear anatomy in well-prepared human labyrinthine bones.materials and methods:thr...

Chronic tinnitus can often be temporally associated with a loss of sensorineural hearing. However, also occur in people normal hearing and thus arise without traceable disorder the inner ear. In present study, we tested whether fine-structure audiometry or high-resolution measurement otoacoustic emissions reveal evidence inner-ear-related disorders that remain undetected by conventional manual ...

In the ENT region 50% of the malformations affect the ear. Malformations of the outer and middle ear are predominantly unilateral (ca. 70-90%) and mostly involve the right ear. Inner ear malformations can be unilateral or bilateral. The incidence of ear malformations is approximately 1 in 3800 newborns. Ear malformations may be genetic (associated with syndromes or not, with family history, spo...