background : to determine the role of letrozole, an aromatase inhibitor,in the treatment of endometriotic pain.   methods: in this prospective, randomized, controlled clinical trial in minimallyinvasive surgery research center,51 women with pelvic endometriosis and endometriotic pain (dyspareunia, dysmenorrhea, pelvic pain) score of 5 or more (for at least one of these endometriotic pain), afte...

angioedema is an asymmetric non-pitting oedema on face, lips, tongue and mucous membranes; any delay in diagnosis and treatment can be fatal. treatment with lisinopril as an angiotensin converting enzyme (ace) inhibitor, can be a reason of angioedema. here we report a case who developed oral-facial edema four years after using lisinopril/hydrochlorothiazide. laryngeal oedema is a main cause of ...

background sivelestat is a neutrophil elastase inhibitor (nei) with positive impact on the respiratory complications in thoracic surgery. based on the findings of a recent study, nei may have a good response for avoiding ischemia reperfusion injury in liver resection. conclusions intravenous nei administration had positive impact on the postoperative inflammatory response and oxygenation while ...

The CAMP-dependent protein kinase (EC 2.7.1.37; ATP:protein phosphotransferase) inhibitor in Sertoli cell-enriched rat testis has been shown to be specifically stimulated by follicle-stimulating hormone in uiuo. Intraperitoneal injection of follicle-stimulating hormone (100 pg of NIH-FSH-S12) induced a significant increase in protein kinase inhibitor 8 h after injection. Maximal stimulation of ...

To elucidate the regulation of serotonin transporter (SERT) function via its membrane trafficking, we investigated involvement ubiquitin E3 ligase HRD1 (HMG-CoA reductase degradation protein), which participates in endoplasmic reticulum (ER)-associated (ERAD), functional SERT. Cells transiently expressing wild-type SERT or a C-terminal deletion mutant (SERTΔCT), protein predicted to be misfolde...

sirtuin1 (sirt1) is an enzyme that deacetylates histones and several nonhistone proteins including p53 during stress and plays an important role in the survival of tumor cells. hereby, this study describes the potency of salermide as a sirt1 inhibitor to induce apoptosis in the mcf-7 and mrc-5 cell lines. mcf7 and mrc-5 cell lines were cultured in rpmi-1640 and treated with or without salermide...

The NF-κB family of transcription factor is a central mediator immune and imflammatory responses. functions as dimer recognize DNA through the two N-terminal domains (NTDs). Previous hydrogen-deuterium exchange mass spectrometry, stopped-flow experiments molecular dynamics simulations suggested NTDs can undergo relative motions which plays an important role in kinetics association dissociation....

Papain-like protease is a SARSCOV-2 that functions for ubiquitination in host cells. Caffeine compounds have been widely reported to antioxidant, anti-inflammatory, antidiabetic, and antiobesity activities. However, hexose malic acid coffee rind as potential inhibitors of the papain-like SARSCOV2 not reported. This study investigated PLPro inhibitor agents inhibiting ubiquitination. In silico s...