angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in  the physiologic circumstances such as embryonic development, placenta formation, and wound healing. it is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. in general, angiogenesis process is a multi-factorial and highly structu...

Abstract Background Gastric cancer is one of the most common malignant tumors digestive system. However, its targeted therapy develops at a slow pace. Thus, exploring mechanisms behavior gastric cells crucial to exploit treatment. Mammalian never-in-mitosis A (NIMA)-related kinases (NEKs) are considered play significant role in cell proliferation. no study has reported on NIMA family proteins c...

GABA is more than the main inhibitory neurotransmitter found in the adult CNS. Several studies have shown that GABA regulates the proliferation of progenitor and stem cells. This work examined the effects of the GABA(A) receptor system on the proliferation of retinal progenitors and non-pigmented ciliary epithelial (NPE) cells. qRT-PCR and whole-cell patch-clamp electrophysiology were used to c...

Objective: To evaluate the inhibition of fibroblast proliferation in vitro conjunctiva obtained by excision pterygium from patients using mitomycin (MMC) and cyclophosphamide (CF). Methods: Pterygiums were removed 7 subjected to cell culture. After cultivation, 3 fragments equal dimensions these tissues collected adjacent areas each patient pterygium. They randomly selected such a way that one ...

Introduction. The occurrence of aortic dissection is related to the proliferation and metastasis vascular smooth muscle cells. In our present study, we found that expression miR-140-5p was inhibited in wall abdominal aorta patients. However, mechanism development unclear. Material methods. We detected NCK Associated Protein 1 (NCKAP1) blood vessel patients normal people by PCR. Next, establishe...

Noni (Morinda citrifolia L.) is one of the many herbs which known as an anticancer agent. Nanoencapsulated form noni extracts could help body absorption and able to inhibit proliferation cancer cells in vitro. This study was conducted examine activity nanoencapsulated vivo anti-proliferation agent cells. extract obtained by maceration method using water a solvent. The nanocapsule made ionic gel...

AIMS Vascular smooth muscle cell (VSMC) proliferation contributes to intima formation after angioplasty or venous by-pass grafting, and during atherosclerosis. VSMC proliferation requires degradation of p27(Kip1) promoted by S-phase kinase-associated protein-2 (Skp2), an F-box protein component of the Skp-Cullin-F-box(Skp2) ubiquitin-ligase. We investigated the role of Rac(1) in the regulation ...

Abstract CD8+ T cell clonal expansion is critical for controlling intracellular infections and tumors. Thus, unravelling the mechanisms that regulate proliferation are imperative to improve vaccine design immunotherapy. However, molecular govern still not fully understood. PDCD4 (Programmed death 4) was shown inhibit translation by sequestering mRNA helicase eIF4A, which leads inhibition of gen...

Luteoloside (Lute), a bioactive natural ingredient, widely exists in nature and possesses hepatoprotective hepatocyte proliferation-promoting properties. This study aimed to investigate whether Lute could counteract non-alcoholic fatty liver disease (NAFLD)-caused damage via its stimulation of regeneration efficacy explore the involved mechanism. LO2 cells primary hepatocytes were used examine ...

Background: Several studies have demonstrated the immunosuppresive effects of mes-enchymal stem cells (MSCs) in allogeneic or mitogenic interactions. Cell-cell contact inhibition and secretion of suppressive soluble factors have been suggested in this re-gard. Objective: To investigate if adipose derived MSCs could inhibit Jurkat lym-phoblastic leukemia T cell proliferation during coculture. Me...