OBJECTIVE To compare the intravenous boluses and intravenous continuous infusion of tranexamic acid (TXA) to reduce postoperative bleeding in cyanotic congenital heart disease surgeries. STUDY DESIGN Single-blinded randomised clinical trial. PLACE AND DURATION OF STUDY Anaesthesia Department, The Aga Khan University Hospital, Karachi, from July 2016 to April 2017. METHODOLOGY Sixty patien...

OBJECTIVES To evaluate and compare the effects of preoperative oral pregabalin and perioperative intravenous lidocaine infusion on postoperative morphine requirement, adverse effects, patients' satisfaction, mobilization, time to first defecation and time to discharge in patients undergoing laparotomy. METHODS Eighty patients (18 to 65 years of age) undergoing elective laparotomy were randoml...

STUDY OBJECTIVE To compare continuous versus intermittent administration of piperacillin-tazobactam with regard to clinical, microbiologic, and economic outcomes. DESIGN Prospective, open-label controlled study SETTING Community teaching hospital. PATIENTS Ninety-eight hospitalized patients prescribed piperacillin-tazobactam. INTERVENTION Substitutions were implemented so that 47 patien...

Poor penetration of vancomycin into Central Nervous System (CNS) can lead to treatmentfailure. The aim of this study was to evaluate and compare CSF concentration and serumpharmacokinetics of high dose vancomycin by continuous infusion vs. intermittent infusion inpost neurosurgical meningitis patients. Twenty patients were divided into two groups. Patientsin intermittent infusion group received...

Poor penetration of vancomycin into Central Nervous System (CNS) can lead to treatmentfailure. The aim of this study was to evaluate and compare CSF concentration and serumpharmacokinetics of high dose vancomycin by continuous infusion vs. intermittent infusion inpost neurosurgical meningitis patients. Twenty patients were divided into two groups. Patientsin intermittent infusion group received...

Clinically encouraging results can be obtained with an intravenous high dose short-time infusion of streptokinase in patients with evolving myocardial infarction. The feasibility and efficacy of the intracoronary and the systemic approach of streptokinase therapy in acute myocardial infarction are discussed in this report and include topics such as infarct artery recanalization success rate, co...

Insulin stimulates the renin-angiotensin system and induces renal vasodilation. The relationship between these opposing influences of insulin on renal vascular tone has not been explored. A hyperinsulinemic euglycemic clamp and sham insulin clamp each of 270 min duration were performed in 15 healthy individuals during high sodium balance. An angiotensin receptor blocker was administered at time...

We describe an adaptive Bayesian design for a clinical trial of an experimental treatment for patients with hematologic malignancies who initially received an allogeneic bone marrow transplant but subsequently suffered a disease recurrence. Treatment consists of up to two courses of targeted immunotherapy followed by allogeneic donor lymphocyte infusion. The immunotherapy is a necessary precurs...

cannabinoids induce diverse responses on anxiolytic–like behaviors. moreover some studies postulated that there is a close relationship between this system and serotonergic system upon cognitive process formation. thus the aim of present study is investigation the possible role of 5-ht 1 receptor on anxiolytic–like behaviors induced by acpa in the elevated plus maze task (epm). in the present s...

Abstract Background The relationship between perioperative red blood cell (RBC) infusion and deep vein thrombosis (DVT) has not been determined. Objectives To analyze the time-event RBC DVT in patients with femoral pelvic fractures after adjusting for confounding factors to provide reference optimizing risk factors. Methods clinical data of 569 who received surgical treatment from May 2018 Dece...