Rheumatoid arthritis, an autoimmune inflammatory disorder is characterized by progressive cartilage erosion leading to joint destruction, pain, stiffness, and swelling. Although the etiology of disease unknown, genetic changes due factors such as environmental agents, immune response towards infectious agents influence rheumatoid arthritis. Earlier NSAIDs were first choice drugs for treatment b...

Inflammatory bowel disease (IBD) is a chronic condition resulting in impaired intestinal homeostasis. Current practices for diagnosis of IBD are challenged by invasive, demanding procedures. We hypothesized that proteomics analysis could provide powerful tool identifying clinical biomarkers non-invasive diagnosis. Here, the global proteomes from commonly used vitro and vivo models were analyzed...

Essential oils from different plant species were found to contain compounds exhibiting anti-inflammatory effects with the potential be a valid alternative conventional chemotherapy that is limited in long-term use due its serious side effects. Generally, first mechanism by which an organism counteracts injurious stimuli inflammation, considered part of innate immune system. Periodontitis infect...

extracts obtained from the petals of rosa damascena (rosaceae) are used in iranian folk medicine as remedies for the treatment of some inflammatory diseases. in this study the hydroalcoholic extract and essential oil of the plant were investigated for its possible anti-inflammatory and analgesic activities. the extract was administered at the doses (p.o.) of 250, 500 and 1000?mg/kg and the dose...

Anti-tumor necrosis factor agents are effective drugs for inflammatory diseases such as rheumatoid arthritis and bowel disease. Although it is indicated the treatment of Ankylosing Spondylitis, there recent publications about paradoxical side effects due to these agents, mostly in form case reports. In this article, we present psoriasis that develops paradoxically a patient with ankylosing spon...

Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...