Neuropathic pain is a pathological pain condition that often results from peripheral nerve injury. Several lines of evidence suggest that neuroinflammation mediated by the interaction between immune cells and neurons plays an important role in the pathogenesis of neuropathic pain. Transient receptor potential melastatin 2 (TRPM2) is a nonselective Ca(2+)-permeable cation channel that acts as a ...

We previously described the in vitro characteristics of the potent and selective CCR1 antagonist, CP-481,715. In addition to being selective for CCR1 vs other chemokine receptors, CP-481,715 is also specific for human CCR1 (hCCR1), preventing its evaluation in classical animal models. To address this, we generated mice whereby murine CCR1 was replaced by hCCR1 (knockin) and used these animals t...

Monthly shallow water-table depths can be predicted from climate forcings on a large scale by the combination of a transfer-function noise (TFN) model with a parameter regionalization scheme. To investigate the sensitivity of regionalized transfer-function noise (RTFN) models, simulations with different input series and parameter regionalization methods, combined with topographic external drift...

A process is described which involves infiltration of aluminum nitrate into partially sintered (porous) zircon bodies. Infiltration kinetics were studied using infiltration curves with two distinct regions. The final infiltrated samples were sintered at 1600 °C for 2 h and yielded specimens containing the tetragonal zirconia.The experimental results show that in spite of the similar porosity of...

In this research, infiltration behavior of W-Ag composite compacts with Nickel and Cobalt as additives has been investigated. Nickel and Cobalt were added to Tungsten powder by two distinct methods: mixing elementally and reduction of salt solution. The coated Tungsten powders were compacted under controlled pressures to make porous skeleton with 32-37 vol. % porosity. Infiltration process was ...

introduction: many patients suffer from mild, moderate or severe pain during or after root canal therapy. theoretically, post-operative pain control can be achieved by using long-acting local anesthetics. the aim of this study was to evaluate the efficacy of a long acting anesthesia, bupivacaine, on preventing post-operative pain associated with endodontic treatment, and to compare it with lido...

background: neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (sci) and these cells cause substantial secondary tissue damage. the purpose of this study was to determine the effect of oleuropein (oe) on myeloperoxidase (mpo) activity as an index of neutrophil infiltration. methods: rats were randomly divided into four groups of 7 rats each as...

Secondhand exposure to environmental tobacco smoke (ETS) in multifamily housing remains a health concern despite strong recommendations to implement non-smoking policies. Multiple studies have documented exposure to ETS in non-smoking units located in buildings with smoking units. However, characterizing the magnitude of ETS infiltration or measuring the impact of building interventions or resi...