OBJECTIVE To assess the level of agreement between common definitions of wound infection that might be used as performance indicators. DESIGN Prospective observational study. SETTING London teaching hospital group receiving emergency cases as well as tertiary referrals. PARTICIPANTS 4773 surgical patients staying in hospital at least two nights. MAIN OUTCOME MEASURES Numbers of wound in...

BACKGROUND Burn wound infection remains the principal cause of death in burn patients. Efficacy of honey and aloe vera gel was evaluated in the treatment of burn wound infection induced with Klebsiella pneumoniae B5055 and their efficacy was compared with an isolated and well-characterized Klebsiella specific phage Kpn5. METHODOLOGY A full thickness burn wound was induced in mice and infected...

Background: To assess the effectiveness of vacuum assisted closure (VAC) therapy for healing of infected wounds. Methods: In this prospective case-control study, total of 25 patients with chronic non-healing wounds were recruited. Before the application of VAC, surgical debridement was performed to remove all the devitalized necrotic tissues as per requirement and the wound was packed with povo...

Pseudomonas aeruginosa infections of wounds in clinical settings are major complications whose outcomes are influenced by host responses that are not completely understood. Herein we evaluated transcriptomic changes of wounds as they counter P. aeruginosa infection-first active infection, and then chronic biofilm infection. We used the dermal full-thickness, rabbit ear excisional wound model. W...

OBJECTIVE To determine the extent of agreement and patterns of disagreement between wound swab and tissue samples in patients with an infected diabetic foot ulcer (DFU). DESIGN Multicentre, prospective, cross-sectional study. SETTING Primary and secondary care foot ulcer/diabetic outpatient clinics and hospital wards across England. PARTICIPANTS Inclusion criteria: consenting patients age...

Objective To assess the level of agreement between common definitions of wound infection that might be used as performance indicators. Design Prospective observational study. Setting London teaching hospital group receiving emergency cases as well as tertiary referrals. Participants 4773 surgical patients staying in hospital at least two nights. Main outcome measures Numbers of wound infections...

This report shows that the antimicrobial peptide (AMP) Epinecidin-1 (Epi-1) efficiently heals MRSA-infected heat burn injuries and provides protection from infection in a pig model. The presence of an optimal level of Epi-1 induces cell proliferation by promoting cell cycle progression through an increase in S-phase cells. Epi-1 also induces proliferation to cover the wounded region in an in vi...

BACKGROUND The cause of death in burn patients after 48 hours of hospitalization has been reported to be bacterial infections. Recently, due to the compounds accelerating the healing process and the intense reduction of treatment side effects, medicinal plants are used to cure burn wound infections. This study aims to investigate the medicinal effect of the ethanolic extract of Scrophularia str...

BACKGROUND Topical antimicrobial therapy of infected diabetic foot ulcers can focus on the wound and avoid the adverse effects of systemic anti-infective agents. We compared the efficacy of outpatient treatment using an investigational topical antimicrobial peptide, pexiganan acetate cream, with the efficacy of systemic therapy using an oral fluoroquinolone antibiotic, ofloxacin, for mildly inf...