Heparin-induced thrombocytopenia (GIT) is a paradoxical reaction of platelets to heparin (their aggregation and destruction), potentially dangerous by the development venous arterial thrombosis, less often bleeding. There are serious problems timely diagnosis this complication. They due both insufficient awareness specialists presence negative psychological attitude. The article presents clinic...

An effective worldwide vaccination campaign started and is still being carried out in the face of coronavirus disease 2019 (COVID-19) pandemic. While vaccines are great tools to confront pandemic, predominantly adenoviral vector-based can cause a rare severe adverse effect, termed vaccine-induced immune thrombocytopenia thrombosis (VITT), about 1 100,000 vaccinated individuals. VITT diagnosed 5...

Endotoxin (lipopolysaccharide, LPS) produced by gram-negative bacteria initiates a host of pro-inflammatory effects through Toll-like receptor 4 (TLR-4). We reported previously that LPS enhances microvascular thrombosis in cremaster venules of wild-type mice, but had no effect in mice deficient in TLR-4. Since TLR-4 is expressed on various cell types, the cellular origin of TLR-4 responsible fo...

Venous thrombosis was induced by ligature of the inferior vena cava in rats whose blood was made hypercoagulable by intravenous (IV) administration of tissue thromboplastin. From a dose-response showing that the administration of increasing doses of tissue thromboplastin resulted in a subsequent progressive increase of thrombus weight, two concentrations of tissue thromboplastin were chosen: a ...

BACKGROUND AND PURPOSE High-dose human albumin is robustly neuroprotective in preclinical ischemia models and is currently in phase III clinical trial for acute ischemic stroke. To explore the hypothesis that albumin's protective effect is mediated in part by salutary intravascular mechanisms, we assessed microvascular hemodynamics in a model of laser-induced cortical arteriolar thrombosis. M...

the acute coronary syndrome due to the left main coronary artery (lmca) thrombosis is a clinically rare and catastrophic event.   we describe a young man ( smoker, alcoholic, and drug abuser) with a history of recent surgery and typical chest pain who had non-occlusive lmca thrombosis in coronary angiography. the thrombosis was successfully treated with two 180 µ/kg intracoronary boluses of ept...

BACKGROUND Patients with acute coronary artery thrombosis often develop primary malignant ventricular arrhythmias (MVA) early after coronary occlusion. In contrast, acute ischemia induced by nonthrombotic balloon occlusion during routine coronary angioplasty rarely elicits such arrhythmias. This study was designed to assess the role of intracoronary thrombosis in arrhythmogenesis during acute i...

Since the role of angiogenesis in cancer development has been recognized, the study of anti-angiogenic or anti-vascular therapeutic agents has become increasingly important for cancer treatment. Selective thrombosis is one approach towards this goal. Since many types of carcinoma accumulate large numbers of degranulating mast cells which will release heparin, intravenously injected protamine ma...

1 Suh JS, Aster RH, Visentin GP. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis recognize different epitopes on heparin: platelet factor 4. Blood 1998; 91:916–922 2 Jang IK, Hursting MJ. When heparins promote thrombosis: review of heparin-induced thrombocytopenia. Circulation 2005; 11:2671–2683 3 Amiral J, Peynaud-Debayle E, Wolf M, et al. Generation of antibodies to ...

background: venous thromboembolism, which comprises deep vein thrombosis and pulmonary embolism and is a significant cause of morbidity and mortality among patients with cancer. the aim of the present study was to report a rare presentation of arterial thrombosis after venous thrombosis in a patient with gastric cancer. report of the case: a 45 year-old female patient with locally advanced gast...