Treatment of pyridine-2-carboxaldehyde with activated alkenes such as alkyl vinyl ketones and cyclic enones in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) provides a novel facile one-pot synthesis of indolizine derivatives, thus for the first time describing an electrophile induced Baylis-Hillman reaction.

Citation Leonard, Effendi et al. " Opportunities in metabolic engineering to facilitate scalable alkaloid production. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract 1 2 Numerous drugs and drug precursors in the current pharmacopoeia 3 originate from plant sources. The limited yield of bioactive compounds in 4 plant...

In recent years, considerable effort has been devoted to develop methodologies which reduce multi-step transformations into one-step tandem processes. In this regard, the use of multifunctional catalysts, which promote sequential reaction steps without additional requirement of additives and/or co-catalysts, provides an effective way while taking care of two most basic challenges faced by a syn...

AIM This study was designed to investigate the bioactive compounds in Costus afer Ker Gawl, an indigenous African medicinal plant whose leaf and stem extracts are used in the treatment of chronic inflammatory diseases, especially rheumatism and arthritis. MATERIALS AND METHODS The bioactive compounds present in the n-butanol fractions of C. afer leaf and stem were identified using qualitative...

We show that mitogenic cells expressing T-type Ca channels (T-channels) are more sensitive to the antiproliferative effects of the drugs pimozide and mibefradil than cells without significant T-channel expression. The growth of Y79 and WERI-Rb1 retinoblastoma cells, as well as MCF7 breast cancer epithelial cells, all of which express T-channel current and mRNA for T-channel subunits, is inhibit...