The synthesis of 1-methyl-3-(arylthio)-1H-indoles has been achieved by the photoredox reaction of N-methylindoles with readily available arylsulfonyl chlorides in moderate yields.

A palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids was achieved. This protocol represents a novel and complementary approach to 2-aroylindoles.

An unprecedented C-3-alkylation reaction of indoles with terminal alkynes in aqueous medium has been developed using catalytic amounts of ruthenium and trifluoroacetic acid.

BACKGROUND Indigoids, as popular dyes, can be produced by microbial strains or enzymes catalysis. However, the new valuable products with their transformation mechanisms, especially inter-conversion among the intermediates and products have not been clearly identified yet. Therefore, it is necessary to investigate novel microbial catalytic processes for indigoids production systematically. FI...

Superelectrophilic 7-chloro-4,6-dinitrobenzofuroxan (DNBF-Cl) and 7-chloro-4,6-dinitrobenzofurazan (DNBZ-Cl) are shown to undergo facile carbon-carbon couplings with a series of weak carbon nucleophiles consisting of a number of differently substituted indoles, 1,2,5-trimethylpyrrole and azulene, in acetonitrile. Despite the fact that steric effects preclude a coplanarity of the donor and accep...

Indole compounds have demanded increasing attention from plant physiologists in recent years since it has become evident that most naturally occurring plant auxins and their precursors are indolic (4). A recent review by Stowe (13) of the simple indoles found in plants clearly demonstrates that the investigator must be prepared to work with a relatively large number of these substances which ar...

This study investigated the effects of chlorpheniramine (CPA, 10-25 mg/kg), diphenhydramine (DIPH, 20 mg/kg), tripelennamine (TRIP, 20 mg/kg), and pyrilamine (PYRI, 20 mg/kg) on 3, 4-methylenedioxymethamphetamine (MDMA, 20 mg/kg x 2)-induced hyperthermia and depletion of indoles in rat brains, on the uptake of serotonin and dopamine into rat synaptosomes, on the binding affinity of CPA for biog...

The occurrence of 5-hydroxytryptamine (serotonin) in normal human urine is suggested by the experiments of Page and his co-workers. Twarog & Page (1953) examined acetone extracts of urine by a pharmacological method (isolated heart of Venus mercenaria) and reported a 'serotonin-like activity' equivalent to 0'1-10yeg. of 5-hydroxytryptamine/ ml. ofurine. Later, Bumpus&Page (1955) described indol...