Close inbreeding has often been shown to be extremely harmful because of the fixation of deleterious recessive alleles in inbred offspring (Charlesworth & Charlesworth 1987). As a consequence, inbred offspring often show reduced fitness compared with outbred offspring (inbreeding depression, Charlesworth & Charlesworth 1987). The ability to identify relatives (kin recognition, Hepper 1991) offe...

Self-indexes are largely studied and widely applied structures in string matching. However, the exact matching of multiple patterns using self-indexes is a topic that has not been the subject of concentrated study although it is an area that may have direct and indirect applications and uses in fields such as bioinformatics. This paper presents a method of improving the exact search of multiple...

BACKGROUND Everolimus and sunitinib have been approved for the treatment advanced pancreatic neuroendocrine tumors, but have not been compared to each other in a randomized trial and have not demonstrated prolonged overall survival compared to placebo. This study aimed to indirectly compare overall and progression-free among everolimus, sunitinib and placebo across separate randomized trials. ...

In schema and ontology matching, background knowledge such as dictionaries and thesauri can considerably improve the mapping quality. Such knowledge resources are especially valuable to determine the semantic relation type (e.g., equal, is-a or part-of) that holds between related concepts. Previous match tools mostly use WordNet as their primary resource for background knowledge, althoughWordNe...

There is an increasing need to interrelate different life science ontologies in order to facilitate data integration or semantic data analysis. Ontology matching aims at a largely automatic generation of mappings between ontologies mostly by calculating the linguistic and structural similarity of their concepts. In this paper we investigate an indirect computation of ontology mappings that comp...

This paper describes a novel system for automatic classification of images obtained from Anti-Nuclear Antibody (ANA) pathology tests on Human Epithelial type 2 (HEp-2) cells using the Indirect Immunofluorescence (IIF) protocol. The IIF protocol on HEp-2 cells has been the hallmark method to identify the presence of ANAs, due to its high sensitivity and the large range of antigens that can be de...

This paper reviews recent advances in the foundations of causal inference and introduces a systematic methodology for defining, estimating and testing causal claims in experimental and observational studies. It is based on non-parametric structural equation models (SEM)– a natural generalization of those used by econometricians and social scientists in the 1950-60s, and provides a coherent math...

many large oil and gas fields in the most productive world regions happen to be fractured. the exploration and development of these reservoirs is a true challenge for many operators. these difficulties are due to uncertainties in geological fracture properties such as aperture, length, connectivity and intensity distribution. to successfully address these challenges, it is paramount to improve ...

This paper reviews recent advances in the foundations of causal inference and introduces a systematic methodology for defining, estimating, and testing causal claims in experimental and observational studies. It is based on nonparametric structural equation models (SEM)—a natural generalization of those used by econometricians and social scientists in the 1950s and 1960s, which provides a coher...