BACKGROUND The American Joint Committee on Cancer (AJCC) staging system (8th edition) for prostate cancer has been published. The current study seeks to validate the prognostic performance of the changes in the new system among clinically staged prostate cancer patients registered within the surveillance, epidemiology and end results (SEER) database. METHODS SEER database (2004-2014) has been...

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The 8th edition of the TNM was released in 2016 and included major revisions, especially for stage III. We aimed to compare the prognostic value of the 7th and 8th editions of the AJCC TNM classification for stage III gastric cancer. Clinical data from 1557 patients operated on for stage III gastric cancer according to the 7th edition between 2007 and 2014 were analyzed and compared using the 7...

OBJECTIVES To investigate the otoprotective effects of mouse nerve growth factor (mNGF) in A/J mice. METHODS The mice at postnatal day 7 (P7) were randomly separated into a mNGF treated group (mNGF group) and a distilled water (for injection) treated group (control group). The mNGF dissolved in distilled water or distilled water alone was given to the mice once every other day from P7 by intr...

BACKGROUND Adult metabolic syndrome may originate in part during fetal or early life. This study was designed to investigate the effects of prenatal exposure to lipopolysaccharide (LPS) on adipose development and local renin-angiotensin system (RAS) activation in rat offspring. METHODS Pregnant rats were randomly divided into three groups (n = 8 in each), including an NS group (pregnant rats ...

Purpose: Traditional clinicopathological variables are used to predict prognosis in differentiated thyroid cancer, including age at diagnosis, tumor size, and extrathyroidal extension (ETE). The American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) 8th edition for thyroid cancer was released in 2016 and included major revisions regarding tumor, node, and metastas...

The Handbook of Neurosurgery 8th Edition by Mark S. Greenberg is an excellent reference for rapid review when a decision about a clinical situation requires a quick review of relevant and adequately detailed information. In this way, The Handbook of Neurosurgery is much more useful in most clinical situations than many of the multi-volume neurosurgery texts available today. The updated version ...