Prolonged periods of muscular inactivity (e.g., limb immobilization) result in skeletal muscle atrophy. Although it is established that reactive oxygen species (ROS) play a role in inactivity-induced skeletal muscle atrophy, the cellular pathway(s) responsible for inactivity-induced ROS production remain(s) unclear. To investigate this important issue, we tested the hypothesis that elevated mit...

OBJECTIVES To evaluate levels of physical activity among physicians in Riyadh, Saudi Arabia and to study the possible factors affecting physical inactivity. In addition, the study aims to estimate the prevalence of major non-communicable diseases (NCDs) and a possible correlation between physical inactivity and major NCDs.  Method: A cross-sectional approach was used for this study conducted on...

OBJECTIVE To ascertain the relationship of physical inactivity and short-term all-cause mortality in a prospective cohort of randomly selected managed care organization members aged 40 years and older who have multiple chronic diseases. METHODS Clinical databases were used to identify all health plan members aged 40 years and older with 2 or more chronic health conditions (hypertension, coron...

Long periods of skeletal muscle inactivity (e.g. prolonged bed rest or limb immobilization) results in a loss of muscle protein and fibre atrophy. This disuse-induced muscle atrophy is due to both a decrease in protein synthesis and increased protein breakdown. Although numerous factors contribute to the regulation of the rates of protein breakdown and synthesis in skeletal muscle, it has been ...

Research on physical activity and fitness indicates their importance in the prevention of disease and promotion of health. However, levels of physical activity have been shown to vary significantly by age, sex and a wide range of additional factors. This paper examines age and sex differences in physical inactivity among 13 to 19 year olds participating in the 1990 Ontario Health Survey. Findin...

Physical activity can help delay, prevent, or manage many of the chronic diseases for which adults aged ≥50 years are at risk (1-3). These diseases can impact the length and quality of life, as well as the long-term ability to live independently.* All adults aged ≥50 years, with or without chronic disease, gain health benefits by avoiding inactivity (2,3). To examine the prevalence of inactivit...

The purpose of this analytical review was to estimate the direct and indirect economic costs of physical inactivity and obesity in Canada in 2001. The relative risks of diseases associated with physical inactivity and obesity were determined from a meta-analysis of existing prospective studies and applied to the health care costs of these diseases in Canada. Estimates were derived for both the ...

BACKGROUND Studies in western countries have revealed that excessive sedentary behavior is a major risk factor for physical inactivity in adolescents. This study was performed to investigate the association between sedentary behavior and physical inactivity in Chinese adolescents using a large-scale cross-sectional survey design. METHODS This study was part of the 2011 Chinese Youth Risk Beha...

D IFFICULTIES ENCOUNTERED in assessing the influence of weightlessness on the circulatory system have previously been discussed, s Problems other than weightlessness which profoundly influence the cardiovascular system must also be considered. One of these in confinement or inactivity resulting in cardiovascular deconditioning. Simulated hypogravic studies done to date all include inactivity as...

This paper evaluates the association between economic environment in the districts of Madrid (Spain) and physical inactivity, using income per capita as indicator of economic environment. The analysis included 6,601 individuals aged 16 to 74 years. The measure of association estimated was the prevalence odds ratio for physical inactivity by income per capita. After adjusting for sex, age, and i...