RIG-I and MDA5 are cytoplasmic RNA sensors that recognize dsRNA patterns and activate MAVS to induce innate antiviral gene program. RNA sensing is regulated by ubiquitination in RIG-I while by phosphorylation in MDA5. Thus, de novo phosphorylation is an essential step for keeping MDA5 inactive. We identified a protein kinase RIO kinase 3 (RIOK3) targeting MDA5, and here discuss its possible rel...

the purpose of this research was to survey the general health and social relationships of active and inactive governmental employees in isfahan city. this research was causal-comparative. the statistical sample included 384 employees of governmental organizations in isfahan who were selected by cluster random sampling manner. a general health questionnaire (ghq 28) and a researcher-made questio...

the aim of the present study was to prepare new cluster (b6c4si) as an antibiotic carrier. density functional theory (dft) method at the b3lyp level of theory in conjugate with the 6-311g** basis set was used to evaluate the interaction between b6c4si cluster and penicillin. binding parameters, homo, lumo and homo- lumo gap were calculated. results show the ‍ b6c4si homo–lumo gap value of 0.13...

background: salmonella is one of the major causes of human diseases related to food consumption. salmonella typhi and s. para-typhi are causes of typhoidal and para-typhoidal infections. some infected individuals recovering from this infection become temporary or permanent carriers, harboring the organisms in the gallbladder, biliary tract, or rarely in their intestines. the aims of this study ...

BACKGROUND/AIMS SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1), kinases controlled by WNK (with-no-K[Lys] kinase), are powerful regulators of cellular ion transport and blood pressure. Observations in gene-targeted mice disclosed an impact of SPAK/OSR1 on phosphate metabolism. The present study thus tested whether SPAK and/or OSR1 contributes to ...