purpose : to investigate the sensations experienced by chinese patients during refractive surgery including the laser in situ keratomileusis (lasik), epi-lasik, and sub-bowman keratomileusis (sbk) techniques. a prospective, randomized, and self-matched clinical study was conducted. methods : the participants included 44 men and 58 women aged 16 to 47 years old (mean 24.3±0.6 years) who underwen...

this study was conducted to determine the chemical composition, digestibility, degradability and nutritive value of madder, rubia tinctorum l.  and alfalfa medicago sativa. using in vitro and in situ measurements. the mean values for om, cp, ndf, adf and ee were 892.5, 172.0, 306.5, 219.4 and 16.0 g/kg dm for madder hay, and 921.3, 141.4, 482.0, 361.1 and 6.50 g/kg dm for alfalfa hay, respectiv...

Treating various ailments of eye utilizes mostly two strategies i.e. delivery of the therapeutic agent by development of a novel delivery system or by enhancing the permeation of therapeutically active agent by the use of penetration enhancers or by the alteration of its physicochemical properties. Conventional ophthalmic drugs delivery system including eye drops, ointments and gels, are no lon...

Objectives Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble dru...

The influence of altitude and salinity on bacterioplankton community composition (BCC) in 16 high-mountain lakes located at altitudes of 2,817 to 5,134 m on the Eastern Qinghai-Xizang (Tibetan) Plateau, China, spanning a salinity gradient from 0.02% (freshwater) to 22.3% (hypersaline), was investigated. Three different methods, fluorescent in situ hybridization, denaturing gradient gel electrop...

Hydroides elegans is a major fouling organism in tropical waters around the world, including Pearl Harbor, Hawaii. To determine the importance of initial surface characteristics on biofilm community composition and subsequent colonization by larvae of H. elegans, the settlement and recruitment of larvae to biofilmed surfaces with six different initial surface wettabilities were tested in Pearl ...

Proposed by Lee and Hirst, the phrase ocular surface squamous neoplasia (OSSN) includes the clinical continuum of mild, moderate, and severe dysplasia, carcinoma in situ, and invasive squamous cell carcinoma (SCC).[1] It is important to understand that dysplasia and carcinoma in situ, together constituting conjunctival intraepithelial neoplasia (CIN), are premalignant by definition, and SCC is ...

The objective of this study was to evaluate the pharmacokinetic characteristics of enrofloxacin (ENR) in situ forming gel in pigs following a single intramuscular administration. Twelve healthy pigs were randomly divided into two groups (6 pigs per group), then administered 20 mg/kg body weight (b.w.) ENR in situ forming gel and 5 mg/kg b.w. ENR conventional injection respectively. Highperforma...

Objective: The present investigation aims to develop nano in situ gels of bevacizumab and evaluate their safety efficacy. Methods: Nanoparticles were designed using the desolvation double emulsion solvent evaporation technique. hen’s egg test: chorioallantoic membrane (HET-CAM) assay was adopted anti-angiogenesis irritancy potential prepared gel. Computational docking study carried out glide mo...