This paper reports a unique approach to immobilize mammalian cell populations (mouse myeloma NS0) through in situ gelation of calcium alginate triggered by an electrical signal under physiologically relevant conditions. This is the first experimental observation to evaluate the electrically triggered assembly of calcium alginate gel for entrapping and culturing mammalian cells. Subsequent cell ...

Different types of in situ gelling systems of indomethacin, in sodium alginate vehicle, were prepared and evaluated for their pharmaceutical properties including viscosity, sterility and drug content uniformity. The gelling efficacy of the prepared systems was evaluated by using an in house fabricated gelation cell. The in vitro release kinetics of the prepared systems was determined in simulat...

The oral delivery of drugs having narrow absorption window in the gastro-intestinal tract is limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the time of absorption. To provide controlled delivery of drugs novel drug delivery systems have been developed. Different systems have been developed to increase the gastric residen...

By William A. Eaton and James Hofrichter T HE FUNDAMENTAL cause ofsickle cell disease is the decreased deformability of the sickled red cell produced by gelation of hemoglobin S. Partial inhibition of gelation should therefore reduce clinical severity, while complete inhibition should result in a “cure.” These basic ideas have stimulated an enormous effort to understand the gelation process in ...

The state of the art in property-process relationships laser polymer powder bed fusion (LPPBF) subcategory (PBF) has derived between energy supplied and thermal properties governing melting degradation, so-called “energy melt ratio (EMR).” EMR provides a framework for process parameter value selection based solely on behavior. However, coalescence, not merely melting, is basis mechanical LPPBF ...

A thorough assessment of gelation progress requires real-time recording biopolymer kinetics. In this study, an in situ investigation with a customized parallel-plate rheometric setup examines how the initial distribution CaCl2 to alginate through micro-holes affects process. At constant volume and concentration reactants, stiffer gels are produced at same probing time by increasing number suppl...