BACKGROUND Irinotecan (IRI) is an integral part of colorectal cancer (CRC) therapy, but response rates are unsatisfactory and resistance mechanisms are still insufficiently understood. As fibroblast growth factor receptor 3 (FGFR3) mediates essential survival signals in CRC, it is a candidate gene for causing intrinsic resistance to IRI. METHODS We have used cell line models overexpressing FG...

The focus of the study is business plan Regional Drinking Water Company (PDAM) East Lombok Regency 2021-2026 . method used mixed methods, namely quantitative and qualitative. result showed that vision PDAM tobe “Health” company toward excellent service self relience. In order to achieve vision, there are 4 missions, objectives, strategy its performance indicator. Performance indicator based BPP...

Health Workforce Australia (HWA) was established by the Council of Australian Governments through its 2008 National Partnership Agreement on Hospital and Health Workforce Reform, as the national agency to progress health workforce reform and address the challenges of providing a skilled, innovative and flexible health workforce in Australia. The Australian Health Ministers' Conference commissio...

Multimodal learning from document data has achieved great success lately as it allows to pre-train semantically meaningful features a prior into learnable downstream task. In this paper, we approach the classification problem by cross-modal representations through language and vision cues, considering intra- inter-modality relationships. Instead of merging different modalities joint representat...

We explain here how to perform branch switching when a singular point is found during higherdimensional continuation on a k-dimensional variety. This document is based on the information given in [1, 2, 3]. Institut de Robòtica i Informàtica Industrial (IRI) Consejo Superior de Investigaciones Cient́ıficas (CSIC) Universitat Politècnica de Catalunya (UPC) Llorens i Artigas 4-6, 08028, Barcelona,...

BACKGROUND Hepatic ischemia and reperfusion injury (IRI) is a major complication in liver surgery, and hepatic steatosis is a primary factor aggravating cellular injury during IRI. Both pro-inflammatory cytokines and reactive oxygen species (ROS) are key mediators of hepatic IRI. Ischemic preconditioning (IpreC), remote ischemia preconditioning (RIPC) and ischemic postconditioning (IpostC) have...

Sutton TA, Wilkinson J, Mang HE, Knipe NL, Plotkin Z, Hosein M, Zak K, Wittenborn J, Dagher PC. p53 regulates renal expression of HIF-1 and pVHL under physiological conditions and after ischemia-reperfusion injury. Am J Physiol Renal Physiol 295: F1666–F1677, 2008. First published September 24, 2008; doi:10.1152/ajprenal.90304.2008.— Ischemia-reperfusion injury (IRI) is a common cause of acute ...