IMPORTANCE Current clinical and immunologic knowledge on cerebellar ataxia (CA) with glutamic acid decarboxylase 65 antibodies (GAD65-Abs) is based on case reports and small series with short-term follow-up data. OBJECTIVE To report the symptoms, additional antibodies, prognostic factors, and long-term outcomes in a cohort of patients with CA and GAD65-Abs. DESIGN, SETTING, AND PARTICIPANTS...

BACKGROUND To report a case of masquerade syndrome presenting as bilateral uveitis in an HCV positive patient, and to highlight the difficulties in distinguishing between chronic uveitis and malignancy-induced inflammation. CASE REPORT In January 2005 a 54-year-old Caucasian man was referred to the Ophthalmological Department for bilateral visual loss, severe vitritis, and a significant catar...

Background: There is limited evidence regarding the impact of Mediterranean Diet (Med Diet) on autoimmune diseases although it has been proposed that adherence to Med may decrease risk certain diseases. However, potential usefulness as a high-quality dietary pattern for other such SLE not yet investigated. Objectives: The aim this study was evaluate association between and disease activity, dam...

Organ transplantation owes its spectacular development in recent decades to the introduction of immunosuppressive drugs capable of preventing allograft rejection. However, vasculopathy remains a major cause of long-term graft failure; thus, a better understanding of its mechanisms is required to improve tolerance. Because endothelial dysfunction is an early manifestation of vascular disorders, ...

BACKGROUND Atopic dermatitis (AD) is a genetically determined pruritic skin disease affecting predominantly young people. The therapy of AD includes mainly corticosteroids (CS), antihistamines and immunosuppressors. CS are known to cause a variety of side effects and attempts have been made to reduce or eliminate their use through alternative methods such as phototherapy (UVA/UVB, UVA(1), UVB 3...

Background Systemic lupus erythematosus (SLE) can impact fertility outcomes and lead to ovarian premature failure. The exact mechanism is not completely understood. Anti-ovarian antibodies have been described as a possible explanation [1] but other intrinsic extrinsic factors are involved. Cyclophosphamide (CYC) known gonadotoxic effect, available data derived from adult cohorts. Anti-müllerian...

Background: Systemic sclerosis (SSc) is an autoimmune disease affecting multiple organs causing morbidity and mortality. Treatments targeting SSc skin often have limited success. The presence of CD30+ lymphocytes in biopsies increased levels serum CD30 been reported patients 1 . This could constitute a new therapeutic target. Objectives: To explore the efficacy safety brentuximab vedotin, chime...

Background In systemic sclerosis (SSc), tailoring treatment to each patient’s needs is challenging and it unclear whether how patients need be treated in the long-term. The feasibility of tapering even withdrawing immunosuppressive therapies with stable disease still an open question. Objectives Using data from Leiden SSc cohort, our aim was describe often modified during a follow-up period 10 ...

Pulmonary infections are a major cause of morbidity and mortality after allogeneic stem-cell transplantation (allo-SCT). Invasive aspergillosis is one of the major causes of pulmonary infection, but viruses are frequently involved, particularly human Cytomegalovirus (CMV). Because of impaired cellular immunity, the risk for pulmonary infections is greatest during the early post engraftment peri...

stimulator (BLyS; also B-cell activation factor) and a proliferation-inducing ligand (APRIL) expression in patients with lupus nephritis and observed a correlation with renal disease activity and APRIL serum levels [1]. In addition, the authors describe that, upon treatment with immunosuppressors, nonresponding patients had higher APRIL serum levels. Th ey thus concluded that APRIL could be a p...